Calmidazolium chloride

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Cat.No. 2561 - Calmidazolium chloride | C31H23Cl7N2O | CAS No. 57265-65-3
Description: Calmodulin antagonist
Alternative Names: R 24571
Chemical Name: 1-[Bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

Calmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca2+-transporting ATPase with IC50 values of 0.15 and 0.35 μM respectively. Also causes elevation of intracellular calcium in HL-60 cells, independent of calmodulin inhibition.

Technical Data

M. Wt 687.7
Formula C31H23Cl7N2O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 57265-65-3
PubChem ID 644274
Smiles [Cl-].ClC1=CC=C(C=C1)C(N1C=C[N+](CC(OCC2=CC=C(Cl)C=C2Cl)C2=CC=C(Cl)C=C2Cl)=C1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 68.77 100
ethanol 68.77 100

Preparing Stock Solutions

The following data is based on the product molecular weight 687.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.45 mL 7.27 mL 14.54 mL
5 mM 0.29 mL 1.45 mL 2.91 mL
10 mM 0.15 mL 0.73 mL 1.45 mL
50 mM 0.03 mL 0.15 mL 0.29 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Gietzen (1983) Comparison of the calmodulin antagonists compound 48/80 and calmidazolium. Biochem.J. 216 611 PMID: 6141789

Harper and Daly (2000) Effect of calmidazolium analogs on calcium influx in HL-60 cells. Biochem.Pharmacol. 60 317 PMID: 10856426

Peppiatt et al (2004) Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells. Biochem.J. 381 929 PMID: 15130089

If you know of a relevant reference for Calmidazolium chloride, please let us know.

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1 Citation for Calmidazolium chloride

Citations are publications that use Tocris products. Selected citations for Calmidazolium chloride include:

Varadarajan et al (2013) Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis. PLoS One 8 e56603 PMID: 23457590

Do you know of a great paper that uses Calmidazolium chloride from Tocris? If so please let us know.

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