Calmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca2+-transporting ATPase with IC50 values of 0.15 and 0.35 μM respectively. Also causes elevation of intracellular calcium in HL-60 cells, independent of calmodulin inhibition.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 687.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.45 mL||7.27 mL||14.54 mL|
|5 mM||0.29 mL||1.45 mL||2.91 mL|
|10 mM||0.15 mL||0.73 mL||1.45 mL|
|50 mM||0.03 mL||0.15 mL||0.29 mL|
References are publications that support the products' biological activity.
Gietzen (1983) Comparison of the calmodulin antagonists compound 48/80 and calmidazolium. Biochem.J. 216 611 PMID: 6141789
Harper and Daly (2000) Effect of calmidazolium analogs on calcium influx in HL-60 cells. Biochem.Pharmacol. 60 317 PMID: 10856426
Peppiatt et al (2004) Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells. Biochem.J. 381 929 PMID: 15130089
If you know of a relevant reference for Calmidazolium chloride, please let us know.
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Keywords: Calmidazolium chloride, supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, R24571, R, 24571, Calcium, Binding, Protein, Calcium, Binding, Protein, Tocris Bioscience
1 Citation for Calmidazolium chloride
Citations are publications that use Tocris products. Selected citations for Calmidazolium chloride include:
Varadarajan et al (2013) Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis. PLoS One 8 e56603 PMID: 23457590
Do you know of a great paper that uses Calmidazolium chloride from Tocris? If so please let us know.
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