MLCK inhibitor peptide 18

Pricing Availability Delivery Time Qty
Cat.No. 1885 - MLCK Inhibitor Peptide 18 | Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2 | CAS No. 224579-74-2
Description: Selective inhibitor of myosin light chain kinase
Alternative Names: Myosin Light Chain Kinase Inhibitor Peptide 18
Datasheet
Citations (1)
Literature

Biological Activity

Selective competitive inhibitor of myosin light chain kinase (IC50 = 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable.

Technical Data

M. Wt 1324.64
Formula C60H105N23O11
Sequence RKKYKYRRK

(Modifications: Lys-9 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 224579-74-2
PubChem ID 10102940
InChI Key JPOKAKNGULMYHZ-UILVTTEASA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1324.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.75 mL 3.77 mL 7.55 mL
5 mM 0.15 mL 0.75 mL 1.51 mL
10 mM 0.08 mL 0.38 mL 0.75 mL
50 mM 0.02 mL 0.08 mL 0.15 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lukas et al (1999) Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge. J.Med.Chem. 42 910 PMID: 10072688

Zolotarevsky et al (2002) A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology 123 163 PMID: 12105845


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1 Citation for MLCK inhibitor peptide 18

Citations are publications that use Tocris products. Selected citations for MLCK inhibitor peptide 18 include:

Wang et al (2012) Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes. Proc Natl Acad Sci U S A 61 2134 PMID: 22688336


Do you know of a great paper that uses MLCK inhibitor peptide 18 from Tocris? If so please let us know.

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