Autocamtide-2-related inhibitory peptide, myristoylated

Pricing Availability Delivery Time Qty
Cat.No. 5959 - Autocamtide-2-related inhibitory peptide, myristoylated | Myr-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu | CAS No. 201422-04-0
Description: CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide
Alternative Names: Myr-AIP, AIP Myristoylated
Datasheet
Citations
Reviews
Literature

Biological Activity

CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide (Cat No. 1688). Pretreatment blocks reinstatement of morphine-seeking behavior in vivo.

Technical Data

M. Wt 1708.12
Formula C78H142N22O20
Sequence KKALRRQEAVDAL

(Modifications: Lys-1 = Myr-Lys)

Storage Store at -20°C
CAS Number 201422-04-0
PubChem ID 121513908
InChI Key QKOOKZWMKXOQRL-YJDHHEDVSA-N
Smiles [H]N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1708.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.59 mL 2.93 mL 5.85 mL
5 mM 0.12 mL 0.59 mL 1.17 mL
10 mM 0.06 mL 0.29 mL 0.59 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Laabich et al (2000) Neuroprotective effect of AIP on N-methyl-D-aspartate-induced cell death in retinal neurons. Brain Res.Mol.Brain Res. 85 32 PMID: 11146104

Liu et al (2012) Inhibition of CaMKII activity in the nucleus accumbens shell blocks the reinstatement of morphine-seeking behavior in rats. Neurosci.Lett. 518 167 PMID: 22579819

Ishida et al (1995) A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem.Biophys.Res.Commun. 212 806 PMID: 7626114


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Citations for Autocamtide-2-related inhibitory peptide, myristoylated

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