SR 11302

Pricing Availability Delivery Time Qty
Cat.No. 2476 - SR 11302 | C26H32O2 | CAS No. 160162-42-5
Description: AP-1 inhibitor; antitumor agent
Chemical Name: (E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (16)
Literature

Biological Activity

Inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo. Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC50 > 1 μM for RARα, RARβ, RARγ and RXRα).

Technical Data

M. Wt 376.54
Formula C26H32O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 160162-42-5
PubChem ID 9976842
InChI Key RQANARBNMTXCDM-DKOHIBGUSA-N
Smiles CC(\C=C\C=C(\C=C\C1=C(C)CCCC1(C)C)C1=CC=C(C)C=C1)=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.6 100
ethanol 3.76 10

Preparing Stock Solutions

The following data is based on the product molecular weight 376.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.28 mL 26.56 mL
5 mM 0.53 mL 2.66 mL 5.31 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Shiohara et al (1999) Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro. Blood 93 2057 PMID: 10068679

Huang et al (1997) Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. Proc.Natl.Acad.Sci.USA 94 5826 PMID:

Fanjul et al (1994) A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Nature 372 107 PMID: 7969403


If you know of a relevant reference for SR 11302, please let us know.

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View all AP-1 Inhibitors

Keywords: SR 11302, supplier, inhibitors, inhibits, AP-1, transcription, factors, antitumor, agent, SR11302, AP-1, AP-1, Tocris Bioscience

16 Citations for SR 11302

Citations are publications that use Tocris products. Selected citations for SR 11302 include:

Keasey et al (2013) Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Commun Signal 11 35 PMID: 23693126

Vliet et al (2013) Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL). J Biol Chem 288 27519 PMID: 23918927

Ivanova et al (2011) Tamoxifen increases nuclear respiratory factor 1 transcription by activating estrogen receptor beta and AP-1 recruitment to adjacent promoter binding sites. FASEB J 25 1402 PMID: 21233487

Sethi et al (2011) Transforming growth factor-β induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells. PLoS One 52 5240 PMID: 21546528

Lee et al (2016) Alternative Splicing of Toll-Like Receptor 9 Transcript in Teleost Fish Grouper Is Regulated by NF-& #954;B Signaling via Phosphorylation of the C-Terminal Domain of the RPB1 Subunit of RNA Polymerase II. PLoS One 11 e0163415 PMID: 27658294

Oruqaj et al (2015) Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling. Proc Natl Acad Sci U S A 112 E2048 PMID: 25848047

Banskota et al (2015) NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7. Mol Cancer 14 123 PMID: 26116564

Lee et al (2015) Anti-cancer effect of snake venom toxin through down regulation of AP-1 mediated PRDX6 expression. Oncotarget 6 22139 PMID: 26061816

Huang et al (2015) p38 mitogen-activated protein kinase/activator protein-1 involved in serum deprivation-induced human alkaline ceramidase 2 upregulation. Int J Gynecol Cancer 3 225 PMID: 25798247

Chen et al (2015) Adrenomedullin Up-regulates the Expression of Vascular Endothelial Growth Factor in Epithelial Ovarian Carcinoma Cells via JNK/AP-1 Pathway. Sci Rep 25 953 PMID: 26098087

Zheng et al (2015) The AP-1 transcription factor homolog Pf-AP-1 activates transcription of multiple biomineral proteins and potentially participates in Pinctada fucata biomineralization. Invest Ophthalmol Vis Sci 5 14408 PMID: 26404494

Kim et al (2014) Self-priming determines high type I IFN production by plasmacytoid dendritic cells. Eur J Immunol 44 807 PMID: 24338737

Bakhru et al (2014) BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9. Cell Immunol 287 53 PMID: 24384074

Mason et al (2014) Effect of prostaglandin E2 on multidrug resistance transporters in human placental cells. Drug Metab Dispos 42 2077 PMID: 25261564

O'Sullivan et al (2014) Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cells. PLoS One 9 e95566 PMID: 24743449

Pernet et al (2014) Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity. Nat Commun 5 5105 PMID: 25290234


Do you know of a great paper that uses SR 11302 from Tocris? If so please let us know.

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