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Biological Activity for T 5224
T 5224 is a selective inhibitor of c-Fos/activator protein (AP)-1. It inhibits the DNA-binding and transactivation activities of AP-1, without affecting the activity of ATF2, C/EBPα, NF-κB/p65, MyoD, and Sp1 in vitro. In a mouse model, T 5224 prevents type II collagen-induced arthritis by reducing inflammatory cytokines (including interleukin 1β) and matrix-degrading MMPs.
Technical Data for T 5224
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for T 5224
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for T 5224
The following data is based on the product molecular weight 517.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.93 mL||9.66 mL||19.32 mL|
|5 mM||0.39 mL||1.93 mL||3.86 mL|
|10 mM||0.19 mL||0.97 mL||1.93 mL|
|50 mM||0.04 mL||0.19 mL||0.39 mL|
References for T 5224
References are publications that support the biological activity of the product.
Tsuchida et al (2006) Discovery of nonpeptidic small-molecule AP-1 inhibitors: lead hopping based on a three-dimensional pharmacophore model. J.Med.Chem 49 80 PMID: 16392794
Aikawa et al (2008) Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1. Nat.Biotechnol 26 817 PMID: 18587386
If you know of a relevant reference for T 5224, please let us know.
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Citations for T 5224
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Literature in this Area
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