Cancer Immunology

Cancer Immunology refers to the relationship between immune function and cancer. The immunological mechanisms involved in cancer growth are highly complex and provide numerous potential points for intervention with small molecules, including extracellular enzymes, receptors and intracellular signal transduction pathways.

Cancer Immunology Product Areas

Although tumor associated antigens are self-antigens, they can be immunogenic as a result of being mutated or overexpressed. This enables the immune system to raise a response to a tumor. However, cancers can evade this immune response by recruiting immunosuppressive cells, including tumor-associated macrophages (TAMs), regulatory T-cells, myeloid-derived suppressor cells and cancer-associated fibroblasts, all of which aid tumor growth. Therapeutic intervention in this system aims either to promote antitumor immune responses or to block the immunosuppressant tumor microenvironment.

A variety of proteins, known as immune checkpoint molecules, also contribute to the ability of tumors to evade the immune system. Immune checkpoint molecules, such as IDO, TDO, PD-1 and CTLA-4, are co-stimulatory or inhibitory proteins that are important in the maintenance of self-tolerance under normal physiological conditions. They are expressed by immune cells, but their expression can be dysregulated in cancers, altering the activation of T cells and/or natural killer (NK) cells and leading to antitumor immunity. Investigation of immune checkpoints should help elucidate the mechanisms by which tumors can avoid the host's immune system.

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

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Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

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Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

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JAK-STAT Pathway

JAK-STAT Signaling Pathway

JAK-STAT signaling is involved in many fundamental cellular processes such as cell proliferation and hematopoiesis. View pathway or download PDF today.

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