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Description: Potent and selective CNS penetrant NUAK1 inhibitor
Chemical Name: (R)-7-(Imidazo[1,2-b]pyridazin-3-yl)-3-(6-methyl-2,6-diazaspiro[3.3]heptan-2-yl)-1-(1-phenylethyl)pyrido[3,4-b]pyrazin-2(1H)-one
Purity: ≥98% (HPLC)
Biological Activity for UCB 9386
UCB 9386 is a potent and selective central nervous system penetrant NUAK1 (NUAK family SnF1-like kinase-1) inhibitor (pIC50= 10.1). Kinome selectivity measured in the diversity panel shows that only Jak2 and Nuak2 are inhibited more than 50% at 10 nM. In vivo, UCB 9386 exhibits high brain penetrance.
Technical Data for UCB 9386
| M. Wt | 478.56 |
| Formula | C27H26N8O |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 172676957 |
| InChI Key | XYKISMBNQVUKPW-GOSISDBHSA-N |
| Smiles | C[C@@H](N1C(C(N2CC3(C2)CN(C3)C)=NC4=C1C=C(C5=CN=C6C=CC=NN65)N=C4)=O)C7=CC=CC=C7 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for UCB 9386
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.86 | 100 | |
| ethanol | 47.86 | 100 |
Preparing Stock Solutions for UCB 9386
The following data is based on the product molecular weight 478.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.09 mL | 10.45 mL | 20.9 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.18 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.09 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
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Product Datasheets for UCB 9386
References for UCB 9386
References are publications that support the biological activity of the product.
Poullennec et al (2024) Discovery of UCB9386: a potent, selective, and brain-penetrant Nuak1 inhibitor suitable for in vivo pharmacological studies. J Med Chem 67 20879 PMID: 39588908
If you know of a relevant reference for UCB 9386, please let us know.
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Pathways for UCB 9386
AMPK Signaling Pathway
AMPK signaling pathway plays an important role in the cellular reponse to low levels of available ATP, often caused by stresses such as heat shock, ischemia or hypoxia.