TANK Binding Kinase

TANK binding kinase (TBK) is a serine/threonine kinase with a critical role in innate immune response and inflammation. This ubiquitously expressed enzyme has a range of substrates leading to additional roles in autophagy, cell proliferation and growth and insulin signaling.

Products
Background
Literature
Pathways

Inhibitors

Cat No Product Name / Activity
4857 Amlexanox
Selective inhibitor of TBK
4318 BX 795
Inhibits TBK; Also inhibits PDPK1, Aurora B and IKKε
5134 MRT 67307 dihydrochloride
Potent inhibitor of TBK; Also inhibits SIK, MARK1-4, IKKε and NUAK1
5067 MRT 68601 hydrochloride
Potent TBK inhibitor

TANK binding kinase (TBK) EC 2.7.11.1 is a ubiquitously expressed serine/threonine kinase belonging to the IκB Kinase (IKK) family, which regulates NF-κB signaling. This kinase has a range of substrates, leading to involvement in multiple pathways including immune response and inflammation, autophagy, cell proliferation and growth and insulin signaling.

TBK has a critical role in innate immunity and inflammation and functions downstream of multiple interferon (IFN) inducing pathways which are activated following pathogen sensing. When toll-like receptors are activated, TBK associates with TANK and TRAF3 to phosphorylate interferon regulatory factors (IRFs). This allows nuclear translocation of IRFs leading to transcriptional activation of antiviral and proinflammatory genes. Additionally, TBK can phosphorylate other transcription factors (STAT6), ubiquitin E3 ligases (Act1, PELI1, TRIM27) and other kinases including IKKα, IKKβ, Akt and mNIK.

TBK has the ability to autophosphorylate and so is highly regulated to avoid aberrant activation. This occurs through intracellular localization; TBK needs to be recruited to signaling complexes by adapter proteins. The physical structure of the TBK protein also limits autophosphorylation.

Certain mutations within the TBK gene are associated with neuroinflammatory and neurodegenerative disorders such as Amylotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Normal Tension Glaucoma (NTG) and Childhood Herpes Encephalitis (HSE). In these conditions mutations in TBK lead to dysregulated autophagy.

External sources of pharmacological information for TANK Binding Kinase :

    Literature for TANK Binding Kinase

    Tocris offers the following scientific literature for TANK Binding Kinase to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


    Immunology

    Immunology Product Listing

    A collection of over 190 products for immunology research, the guide includes research tools for the study of:

    • Chemokine and Cytokine Signaling
    • Chemotaxis
    • Complement System
    • Immune Cell Signaling
    • Inflammation
    Kinases

    Kinases Product Listing

    A collection of over 400 products for kinase research, the listing includes inhibitors of:

    • Receptor Tyrosine Kinases
    • Protein Kinases A, C, D and G
    • PI-3 Kinase, Akt and mTOR
    • MAPK Signaling
    • Receptor Serine/Threonine Kinases
    Autophagy

    Autophagy Scientific Review

    Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.

    Autophagy

    Autophagy Poster

    Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.

    Pathways for TANK Binding Kinase

    NF-κB

    NF-κB Signaling Pathway

    NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.
    Toll-like Receptor

    Toll-like Receptor Signaling Pathway

    TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.