NF-κB Signaling Pathway
IKKγ/
NEMO IKKγ/
NEMO IKKγ/
NEMO IKKα GSK-3β IKKβ CK2 Ras NF-κB1
p50 NF-κB1
p50 NF-κB2
p52 NF-κB2
p52 PKC PKC IκBα IκBα RSK PI3K Akt p38
MAPK GFR
NEMO IKKγ/
NEMO IKKγ/
NEMO IKKα GSK-3β IKKβ CK2 Ras NF-κB1
p50 NF-κB1
p50 NF-κB2
p52 NF-κB2
p52 PKC PKC IκBα IκBα RSK PI3K Akt p38
MAPK GFR
Nuclear factor kappa B signaling plays an important role in inflammation and the immune and stress responses. Adaptor proteins recruit the IKK complex which phosphorylates and degrades IκB, allowing NF-κB to translocate to the nucleus. Dysregulation of NF-κB signaling can lead to inflammatory and autoimmune disease and cancer.
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Signaling Pathway Key
Stimulates
Inhibits
Multistep Activation
Translocates
Kinase
Transcription Factor
Enzyme-linked Receptor
Other Protein
Nuclear Receptor
