Potent and selective TASK-1 (K2P3.1/KCNK3) channel blocker (IC50 values are 4 and 390 nM at TASK-1 and TASK-3, respectively). Displays little or no inhibition at Kir2.1, voltage-gated potassium channels, KCNQ2 and KV11.1 (hERG).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 360.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.77 mL||13.87 mL||27.75 mL|
|5 mM||0.55 mL||2.77 mL||5.55 mL|
|10 mM||0.28 mL||1.39 mL||2.77 mL|
|50 mM||0.06 mL||0.28 mL||0.55 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Flaherty et al (2014) Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorg.Med.Chem.Lett. 24 3968 PMID: 25017033
Zou et al (2013) ML365: Development of bis-amides as selective inhibitors of the KCNK3/TASK1 two pore potassium channel. Probe Reports from the NIH Molecular Libraries Program PMID: 24479195
If you know of a relevant reference for ML 365, please let us know.
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Citations for ML 365
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Literature in this Area
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