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Submit ReviewML 365 is a potent and selective TASK-1 (K2P3.1/KCNK3) channel blocker (IC50 values are 4 and 390 nM at TASK-1 and TASK-3, respectively). Displays little or no inhibition at Kir2.1, voltage-gated potassium channels, KCNQ2 and KV11.1 (hERG).
ML 365 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
M. Wt | 360.41 |
Formula | C22H20N2O3 |
Storage | Store at +4°C |
Purity | ≥99% (HPLC) |
CAS Number | 947914-18-3 |
PubChem ID | 46785920 |
InChI Key | UTAJHKSGYJSZBR-UHFFFAOYSA-N |
Smiles | CC1=CC=CC(C(NC2=CC(NC(C3=CC=CC=C3OC)=O)=CC=C2)=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 36.04 | 100 | |
ethanol | 18.02 | 50 |
The following data is based on the product molecular weight 360.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.77 mL | 13.87 mL | 27.75 mL |
5 mM | 0.55 mL | 2.77 mL | 5.55 mL |
10 mM | 0.28 mL | 1.39 mL | 2.77 mL |
50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
References are publications that support the biological activity of the product.
Flaherty et al (2014) Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorg.Med.Chem.Lett. 24 3968 PMID: 25017033
Zou et al (2013) ML365: Development of bis-amides as selective inhibitors of the KCNK3/TASK1 two pore potassium channel. Probe Reports from the NIH Molecular Libraries Program PMID: 24479195
If you know of a relevant reference for ML 365, please let us know.
Keywords: ML 365, ML 365 supplier, ML365, Potassium, channels, subfamily, K, member, 3, k2p3.1, KCNK3, potent, selective, TASK1, inhibitors, inhibits, TASK3, TWIK, related, acid, sensitive, K+, two, pore, potassium, channel, Two-P, Channels, 5337, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for ML 365 include:
Pagani et al (2019) How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch. Neuron PMID: 31103358
Vierra et al (2017) TALK-1 channels control β cell endoplasmic reticulum Ca2+ homeostasis. Sci Signal 10 PMID: 28928238
Veldkamp et al (2018) Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel. Nat. Commun. 9 4357 PMID: 30341287
Do you know of a great paper that uses ML 365 from Tocris? Please let us know.
Average Rating: 5 (Based on 1 Review.)
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This product was used to study the channel blocking activity on K2p1.1 channels. It was identified that it shows certain degree of channel blocking although that is not concentration dependent. Would buy again as the results obtained were reproducible at every trial study.
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.