BL 1249

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Cat.No. 3797 - BL 1249 | C17H17N5 | CAS No. 18200-13-0
Description: Putative K2P2.1 (TREK-1) channel opener
Chemical Name: 5,6,7,8-Tetrahydro-N-[2-(2H-tetrazol-5-yl)phenyl]-1-naphthalenamine
Purity: ≥99% (HPLC)

Biological Activity

Putative potassium channel activator; thought to act as a K2P2.1 (TREK-1) channel opener. Exhibits selectivity for bladder over vascular tissue in vitro and in vivo (EC50 values are 1.26 and 21.0 μM for cultured bladder and aortic tissues respectively).

Technical Data

M. Wt 291.35
Formula C17H17N5
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 18200-13-0
PubChem ID 16078951
Smiles C1(NC3=CC=CC4=C3CCCC4)=CC=CC=C1C2=NN=NN2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
1eq. NaOH 29.14 100
DMSO 29.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 291.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.16 mL 34.32 mL
5 mM 0.69 mL 3.43 mL 6.86 mL
10 mM 0.34 mL 1.72 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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Product Datasheets

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References are publications that support the products' biological activity.

Tertyshnikova et al (2005) BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: a putative potassium channel opener with bladder-relaxant properties. J.Pharmacol.Exp.Ther. 313 250 PMID: 15608074

Gonczi et al (2006) Investigation of the role of TASK-2 channels in rat pulmonary arteries; pharmacological and functional studies following RNA interference procedures. Br.J.Pharmacol. 147 496 PMID: 16432512

If you know of a relevant reference for BL 1249, please let us know.

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