BL 1249

Pricing Availability   Qty
Cat.No. 3797 - BL 1249 | C17H17N5 | CAS No. 18200-13-0
Description: K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator
Chemical Name: 5,6,7,8-Tetrahydro-N-[2-(2H-tetrazol-5-yl)phenyl]-1-naphthalenamine
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature (5)

Biological Activity

K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel opener (EC50 values are 5.5 μM and 8 μM, respectively). Exhibits selectivity for bladder over vascular tissue in vitro and in vivo (EC50 values are 1.26 and 21.0 μM for cultured bladder and aortic tissues respectively).

Technical Data

M. Wt 291.35
Formula C17H17N5
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 18200-13-0
PubChem ID 16078951
InChI Key YYNRZIFBTOUICE-UHFFFAOYSA-N
Smiles C1(NC3=CC=CC4=C3CCCC4)=CC=CC=C1C2=NN=NN2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 29.14 100
DMSO 29.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 291.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.16 mL 34.32 mL
5 mM 0.69 mL 3.43 mL 6.86 mL
10 mM 0.34 mL 1.72 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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References

References are publications that support the biological activity of the product.

Tertyshnikova et al (2005) BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: a putative potassium channel opener with bladder-relaxant properties. J.Pharmacol.Exp.Ther. 313 250 PMID: 15608074

Gonczi et al (2006) Investigation of the role of TASK-2 channels in rat pulmonary arteries; pharmacological and functional studies following RNA interference procedures. Br.J.Pharmacol. 147 496 PMID: 16432512

Pope et al (2018) Protein and chemical determinants of BL-1249 action and selectivity for K2P channels. ACS Chem.Neurosci. 9 3153 PMID: 30089357


If you know of a relevant reference for BL 1249, please let us know.

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Keywords: BL 1249, BL 1249 supplier, BL1249, potassium, channel, activators, openers, K2p2.1, trek-1, kcnk2, tpkc1, bladder, selective, Two-P, Potassium, Channels, 3797, Tocris Bioscience

1 Citation for BL 1249

Citations are publications that use Tocris products. Selected citations for BL 1249 include:

Fernandez-Fernandez et al (2018) Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons. PLoS One 13 e0199282 PMID: 29928032


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Reviews for BL 1249

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BL 1249 performed ideally on biology lab conditions.
By Anonymous on 10/31/2018
Assay Type: In Vitro
Species: Human

Great potassium channel activator. Was studied on potassium channel expressed on human brain cells. The product performed well under experimental conditions and would purchase again.

The product dissolved in DMSO must be handled carefully as it easily crosses cell membrane.

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Literature in this Area

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