You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for BL 1249
BL 1249 is a K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel opener (EC50 values are 5.5 μM and 8 μM, respectively). Exhibits selectivity for bladder over vascular tissue in vitro and in vivo (EC50 values are 1.26 and 21.0 μM for cultured bladder and aortic tissues respectively).
Technical Data for BL 1249
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BL 1249
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for BL 1249
The following data is based on the product molecular weight 291.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.43 mL||17.16 mL||34.32 mL|
|5 mM||0.69 mL||3.43 mL||6.86 mL|
|10 mM||0.34 mL||1.72 mL||3.43 mL|
|50 mM||0.07 mL||0.34 mL||0.69 mL|
References for BL 1249
References are publications that support the biological activity of the product.
Tertyshnikova et al (2005) BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: a putative potassium channel opener with bladder-relaxant properties. J.Pharmacol.Exp.Ther. 313 250 PMID: 15608074
Gonczi et al (2006) Investigation of the role of TASK-2 channels in rat pulmonary arteries; pharmacological and functional studies following RNA interference procedures. Br.J.Pharmacol. 147 496 PMID: 16432512
Pope et al (2018) Protein and chemical determinants of BL-1249 action and selectivity for K2P channels. ACS Chem.Neurosci. 9 3153 PMID: 30089357
If you know of a relevant reference for BL 1249, please let us know.
View Related Products by Product Action
Keywords: BL 1249, BL 1249 supplier, BL1249, potassium, channel, activators, openers, K2p2.1, trek-1, kcnk2, tpkc1, bladder, selective, Two-P, Potassium, Channels, 3797, Tocris Bioscience
2 Citations for BL 1249
Citations are publications that use Tocris products. Selected citations for BL 1249 include:
Fernandez-Fernandez et al (2018) Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons. PLoS One 13 e0199282 PMID: 29928032
Koichi et al (2019) TREK-1 and TRAAK Are Principal K+ Channels at the Nodes of Ranvier for Rapid Action Potential Conduction on Mammalian Myelinated Afferent Nerves. Neuron 104 960-971.e7 PMID: 31630908
Do you know of a great paper that uses BL 1249 from Tocris? Please let us know.
Reviews for BL 1249
Average Rating: 5 (Based on 1 Review.)
Have you used BL 1249?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Great potassium channel activator. Was studied on potassium channel expressed on human brain cells. The product performed well under experimental conditions and would purchase again.
The product dissolved in DMSO must be handled carefully as it easily crosses cell membrane.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.