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Description: Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) blocker
Chemical Name: N-[(2,4-Difluorophenyl)methyl]-2'-[[[2-(4-methoxyphenyl)acetyl]amino]methyl][1,1'-biphenyl]-2-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for A 1899
A 1899 is a potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) channel blocker (IC50 values are 7 nM and 70 nM for human TASK-1 and TASK-3 expressed in CHO cells, respectively). Displays >12.5-fold selectivity for TASK-1 and TASK-3 over other K+ channels (IC50 = 0.9 μM for K2P18.1/TRESK and >2 μM for all other channels tested). Binds within open channel pore.
Compound Libraries for A 1899
A 1899 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for A 1899
| M. Wt | 500.55 |
| Formula | C30H26F2N2O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 498577-46-1 |
| PubChem ID | 9827303 |
| InChI Key | IXKPEYHRIVQTCU-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(C=C1)CC(NCC2=C(C3=C(C(NCC4=C(C=C(C=C4)F)F)=O)C=CC=C3)C=CC=C2)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for A 1899
References for A 1899
References are publications that support the biological activity of the product.
Streit et al (2011) A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore. J.Biol.Chem. 286 13977 PMID: 21362619
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Keywords: A 1899, A 1899 supplier, A1899, potassium, channel, two, pore, blockers, blocks, task1, task-1, task3, potent, Two-P, Potassium, Channels, 6972, Tocris Bioscience
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