PE 22-28

Pricing Availability   Qty
Description: Potent inhibitor of TREK-1 channels
Purity: ≥95% (HPLC)

Biological Activity for PE 22-28

PE 22-28 is a potent inhibitor of potassium channel subfamily K member 2/TREK-1 (IC50 = 0.12 nM). In rodent models of ischemia PE 22-28 reduces apoptotic death of β cells, increases hippocampal neurogenesis, and reduces stroke-induced motor and cognitive defects.

Technical Data for PE 22-28

M. Wt 773.89
Formula C35H55N11O9
Sequence GVSWGLR
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1801959-12-5
PubChem ID 165437303
Smiles O=C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)CN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PE 22-28

Solubility Soluble to 2 mg/ml in water

References for PE 22-28

References are publications that support the biological activity of the product.

Daziano et al (2021) Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathway. Pharmacol.Res. 167 105539 PMID: 33737242

Pietri et al (2019) First evidence of protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptides. Neuropharmacology 158 107715 PMID: 31325429

If you know of a relevant reference for PE 22-28, please let us know.

View Related Products by Product Action

View all Two-P Potassium Channel Inhibitors

Keywords: PE 22-28, PE 22-28 supplier, PE2228, TREK1, TREK, inhibitor, inhibits, inhibitors, potent, ischemia, beta, cells, neurogenesis, neuroprotective, potassium, channel, subfamily, K, member, 2, Two-P, Potassium, Channels, 7868, Tocris Bioscience

Citations for PE 22-28

Citations are publications that use Tocris products.

Currently there are no citations for PE 22-28. Do you know of a great paper that uses PE 22-28 from Tocris? Please let us know.

Reviews for PE 22-28

There are currently no reviews for this product. Be the first to review PE 22-28 and earn rewards!

Have you used PE 22-28?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review