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Biological Activity for PE 22-28
PE 22-28 is a potent inhibitor of potassium channel subfamily K member 2/TREK-1 (IC50 = 0.12 nM). In rodent models of ischemia PE 22-28 reduces apoptotic death of β cells, increases hippocampal neurogenesis, and reduces stroke-induced motor and cognitive defects.
Technical Data for PE 22-28
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PE 22-28
|Solubility||Soluble to 2 mg/ml in water|
References for PE 22-28
References are publications that support the biological activity of the product.
Daziano et al (2021) Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathway. Pharmacol.Res. 167 105539 PMID: 33737242
Pietri et al (2019) First evidence of protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptides. Neuropharmacology 158 107715 PMID: 31325429
If you know of a relevant reference for PE 22-28, please let us know.
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Citations for PE 22-28
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Currently there are no citations for PE 22-28. Do you know of a great paper that uses PE 22-28 from Tocris? Please let us know.
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