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Submit ReviewTerbinafine hydrochloride
Description: Selective K2P9.1 (TASK-3) activator; also inhibits fungal squalene epoxidase
Chemical Name: N-[(2E)-6,6-Dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Terbinafine hydrochloride
Terbinafine hydrochloride is a selective TASK3 activator (pEC50 = 6.2). Exhibits >10-fold selectivity for TASK3 over TREK2, TRESK, THIK1 and TASK2. Also inhibits TWIK1 (pIC50 = 5.69). Also antifungal; inhibits fungal sterol biosynthesis by inhibition of squalene epoxidase.
Technical Data for Terbinafine hydrochloride
| M. Wt | 327.89 |
| Formula | C21H25N.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 78628-80-5 |
| PubChem ID | 5282481 |
| InChI Key | BWMISRWJRUSYEX-SZKNIZGXSA-N |
| Smiles | CN(CC1=CC=CC2=C1C=CC=C2)C/C=C/C#CC(C)(C)C.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Terbinafine hydrochloride
References for Terbinafine hydrochloride
References are publications that support the biological activity of the product.
Petranyi et al (1984) Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. Science 224 1239 PMID: 6547247
Wright et al (2017) Terbinafine is a novel and selective activator of the two-pore domain potassium channel TASK3. Biochem.Biophys.Res.Commun. 493 444 PMID: 28882594
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Keywords: Terbinafine hydrochloride, Terbinafine hydrochloride supplier, K2P, selective, TASK3, activators, activates, squalene, epoxidase, monooxygenase, inhibitors, inhibits, antifungal, antimycotic, Two-P, Potassium, Channels, Other, Oxygenases/Oxidases, Antifungals, 6484, Tocris Bioscience
1 Citation for Terbinafine hydrochloride
Citations are publications that use Tocris products. Selected citations for Terbinafine hydrochloride include:
Richard L et al (2021) Modulation of TASK-1/3 channels at the hypoglossal motoneuron pool and effects on tongue motor output and responses to excitatory inputs in vivo: implications for strategies for obstructive sleep apnea pharmacotherapy. Sleep 44 PMID: 32745213
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