Terbinafine hydrochloride

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Cat.No. 6484 - Terbinafine hydrochloride | C21H25N.HCl | CAS No. 78628-80-5
Description: Selective TASK3 activator; also inhibits fungal squalene epoxidase
Chemical Name: N-[(2E)-6,6-Dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective TASK3 activator (pEC50 = 6.2). Exhibits >10-fold selectivity for TASK3 over TREK2, TRESK, THIK1 and TASK2. Also inhibits TWIK1 (pIC50 = 5.69). Also antifungal; inhibits fungal sterol biosynthesis by inhibition of squalene epoxidase.

Technical Data

M. Wt 327.89
Formula C21H25N.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 78628-80-5
PubChem ID 5282481
InChI Key BWMISRWJRUSYEX-SZKNIZGXSA-N
Smiles CN(CC1=CC=CC2=C1C=CC=C2)C/C=C/C#CC(C)(C)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.79 100
water 3.28 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 327.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.05 mL 15.25 mL 30.5 mL
5 mM 0.61 mL 3.05 mL 6.1 mL
10 mM 0.3 mL 1.52 mL 3.05 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Petranyi et al (1984) Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. Science 224 1239 PMID: 6547247

Wright et al (2017) Terbinafine is a novel and selective activator of the two-pore domain potassium channel TASK3. Biochem.Biophys.Res.Commun. 493 444 PMID: 28882594


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Citations for Terbinafine hydrochloride

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