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Submit ReviewAM 0902
Description: Potent and selective TRPA1 antagonist
Chemical Name: 1-[[3-[2-(4-Chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl-6H-purin-6-one
Purity: ≥98% (HPLC)
Biological Activity for AM 0902
AM 0902 is a potent and selective TRPA1 antagonist (IC50 = 0.02 μM for human TRPA1). Exhibits no siginificant activity against human TRPV1 or TRPV4, and rat TRPV1, TRPV3 or TRPM8. Exhibits efficacy in a rat pain model. Orally bioavailable.
Compound Libraries for AM 0902
AM 0902 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for AM 0902
| M. Wt | 370.79 |
| Formula | C17H15ClN6O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1883711-97-4 |
| PubChem ID | 73297271 |
| InChI Key | AWJBWNUUODWOKQ-UHFFFAOYSA-N |
| Smiles | CN1C=NC2=C1C(N(C=N2)CC3=NC(CCC4=CC=C(C=C4)Cl)=NO3)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AM 0902
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.08 | 100 |
Preparing Stock Solutions for AM 0902
The following data is based on the product molecular weight 370.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.7 mL | 13.48 mL | 26.97 mL |
| 5 mM | 0.54 mL | 2.7 mL | 5.39 mL |
| 10 mM | 0.27 mL | 1.35 mL | 2.7 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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Product Datasheets for AM 0902
References for AM 0902
References are publications that support the biological activity of the product.
Schenkel et al (2016) Optimization of a novel quinazolinone-based series of transient receptor potential A1 (TRPA1) antagonists demonstrating potent in vivo activity. J.Med.Chem. 59 2794 PMID: 26942860
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Keywords: AM 0902, AM 0902 supplier, AM0902, analgesic, potent, selective, transient, receptor, potential, A1, TRPA1, antagonists, antagonism, orally, bioavailable, 5914, Tocris Bioscience
1 Citation for AM 0902
Citations are publications that use Tocris products. Selected citations for AM 0902 include:
Silverman et al (2023) Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1 beta induced hypothermia and reflex anti-inflammatory responses Mol Med 29 4 PMID: 36650454
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Pain Research Product Guide
A collection of over 280 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Pain Poster
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.