AM 0902

Pricing Availability   Qty
Description: Potent and selective TRPA1 antagonist
Chemical Name: 1-[[3-[2-(4-Chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl-6H-purin-6-one
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews

Biological Activity for AM 0902

AM 0902 is a potent and selective TRPA1 antagonist (IC50 = 0.02 μM for human TRPA1). Exhibits no siginificant activity against human TRPV1 or TRPV4, and rat TRPV1, TRPV3 or TRPM8. Exhibits efficacy in a rat pain model. Orally bioavailable.

Compound Libraries for AM 0902

AM 0902 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AM 0902

M. Wt 370.79
Formula C17H15ClN6O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1883711-97-4
PubChem ID 73297271
InChI Key AWJBWNUUODWOKQ-UHFFFAOYSA-N
Smiles CN1C=NC2=C1C(N(C=N2)CC3=NC(CCC4=CC=C(C=C4)Cl)=NO3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AM 0902

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.08 100

Preparing Stock Solutions for AM 0902

The following data is based on the product molecular weight 370.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.7 mL 13.48 mL 26.97 mL
5 mM 0.54 mL 2.7 mL 5.39 mL
10 mM 0.27 mL 1.35 mL 2.7 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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References for AM 0902

References are publications that support the biological activity of the product.

Schenkel et al (2016) Optimization of a novel quinazolinone-based series of transient receptor potential A1 (TRPA1) antagonists demonstrating potent in vivo activity. J.Med.Chem. 59 2794 PMID: 26942860


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Keywords: AM 0902, AM 0902 supplier, AM0902, analgesic, potent, selective, transient, receptor, potential, A1, TRPA1, antagonists, antagonism, orally, bioavailable, 5914, Tocris Bioscience

4 Citations for AM 0902

Citations are publications that use Tocris products. Selected citations for AM 0902 include:

Hong et al (2019) Endogenous transient receptor potential ankyrin 1 and vanilloid 1 activity potentiates glutamatergic input to spinal lamina I neurons in inflammatory pain. J Neurochem 149 381-398 PMID: 30716174

Adele M et al (2022) Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain. Sci Adv 8 eabo5633 PMID: 35921423

Silverman et al (2023) Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1 beta induced hypothermia and reflex anti-inflammatory responses Mol Med 29 4 PMID: 36650454

Miriam et al (2020) Lipid Oxidation Induced by RF Waves and Mediated by Ferritin Iron Causes Activation of Ferritin-Tagged Ion Channels. Cell Rep 30 3250-3260.e7 PMID: 32160534


Do you know of a great paper that uses AM 0902 from Tocris? Please let us know.

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