AM 0902

Pricing Availability   Qty
Cat.No. 5914 - AM 0902 | C17H15ClN6O2 | CAS No. 1883711-97-4
Description: Potent and selective TRPA1 antagonist
Chemical Name: 1-[[3-[2-(4-Chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl-6H-purin-6-one
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for AM 0902

AM 0902 is a potent and selective TRPA1 antagonist (IC50 = 0.02 μM for human TRPA1). Exhibits no siginificant activity against human TRPV1 or TRPV4, and rat TRPV1, TRPV3 or TRPM8. Exhibits efficacy in a rat pain model. Orally bioavailable.

Compound Libraries for AM 0902

AM 0902 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AM 0902

M. Wt 370.79
Formula C17H15ClN6O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1883711-97-4
PubChem ID 73297271
Smiles CN1C=NC2=C1C(N(C=N2)CC3=NC(CCC4=CC=C(C=C4)Cl)=NO3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AM 0902

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.08 100

Preparing Stock Solutions for AM 0902

The following data is based on the product molecular weight 370.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.7 mL 13.48 mL 26.97 mL
5 mM 0.54 mL 2.7 mL 5.39 mL
10 mM 0.27 mL 1.35 mL 2.7 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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References for AM 0902

References are publications that support the biological activity of the product.

Schenkel et al (2016) Optimization of a novel quinazolinone-based series of transient receptor potential A1 (TRPA1) antagonists demonstrating potent in vivo activity. J.Med.Chem. 59 2794 PMID: 26942860

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Citations for AM 0902

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Literature in this Area

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Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
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Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.