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Biological Activity for AM 0902
AM 0902 is a potent and selective TRPA1 antagonist (IC50 = 0.02 μM for human TRPA1). Exhibits no siginificant activity against human TRPV1 or TRPV4, and rat TRPV1, TRPV3 or TRPM8. Exhibits efficacy in a rat pain model. Orally bioavailable.
Compound Libraries for AM 0902
Technical Data for AM 0902
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AM 0902
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AM 0902
The following data is based on the product molecular weight 370.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.7 mL||13.48 mL||26.97 mL|
|5 mM||0.54 mL||2.7 mL||5.39 mL|
|10 mM||0.27 mL||1.35 mL||2.7 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
References for AM 0902
References are publications that support the biological activity of the product.
Schenkel et al (2016) Optimization of a novel quinazolinone-based series of transient receptor potential A1 (TRPA1) antagonists demonstrating potent in vivo activity. J.Med.Chem. 59 2794 PMID: 26942860
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Keywords: AM 0902, AM 0902 supplier, AM0902, analgesic, potent, selective, transient, receptor, potential, A1, TRPA1, antagonists, antagonism, orally, bioavailable, 5914, Tocris Bioscience
4 Citations for AM 0902
Citations are publications that use Tocris products. Selected citations for AM 0902 include:
Adele M et al (2022) Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain. Sci Adv 8 eabo5633 PMID: 35921423
Silverman et al (2023) Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1 beta induced hypothermia and reflex anti-inflammatory responses Mol Med 29 4 PMID: 36650454
Hong et al (2019) Endogenous transient receptor potential ankyrin 1 and vanilloid 1 activity potentiates glutamatergic input to spinal lamina I neurons in inflammatory pain. J Neurochem 149 381-398 PMID: 30716174
Miriam et al (2020) Lipid Oxidation Induced by RF Waves and Mediated by Ferritin Iron Causes Activation of Ferritin-Tagged Ion Channels. Cell Rep 30 3250-3260.e7 PMID: 32160534
Do you know of a great paper that uses AM 0902 from Tocris? Please let us know.
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