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Selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat). Displays little or no affinity at more than 60 other related receptors, channels and enzymes. Stimulates 5-HT release from QGP-1 cells. Exhibits an abdominal analgesic effect in vivo. Orally bioavailable.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 263.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.8 mL||18.99 mL||37.99 mL|
|5 mM||0.76 mL||3.8 mL||7.6 mL|
|10 mM||0.38 mL||1.9 mL||3.8 mL|
|50 mM||0.08 mL||0.38 mL||0.76 mL|
References are publications that support the biological activity of the product.
Kojima et al (2014) Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain. Eur.J.Pharmacol. 723 288 PMID: 24291101
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Keywords: ASP 7663, ASP 7663 supplier, ASP7663, transient, receptor, potential, ankyrin, 1, selective, TRPA1, activators, activates, anticonstipation, abdominal, analgesics, 5HT, 5178, Tocris Bioscience
2 Citations for ASP 7663
Citations are publications that use Tocris products. Selected citations for ASP 7663 include:
Blaha et al (2019) Bladder Dysfunction in an Obese Zucker Rat: The Role of TRPA1 Channels, Oxidative Stress, and Hydrogen Sulfide. Oxid Med Cell Longev 2019 5641645 PMID: 31531184
Ko et al (2019) A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery. Sci Rep 9 2430 PMID: 30787340
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.