ASP 7663

Pricing Availability   Qty
Cat.No. 5178 - ASP 7663 | C14H14FNO3 | CAS No. 1190217-35-6
Description: Selective TRPA1 activator
Chemical Name: (2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat). Displays little or no affinity at more than 60 other related receptors, channels and enzymes. Stimulates 5-HT release from QGP-1 cells. Exhibits an abdominal analgesic effect in vivo. Orally bioavailable.

Technical Data

M. Wt 263.26
Formula C14H14FNO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1190217-35-6
PubChem ID 44232532
InChI Key RCVZUIGCNAAMIC-UXBLZVDNSA-N
Smiles O=C2/C(C1=CC=CC(F)=C1N2CC(C)C)=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 26.33 100
DMSO 26.33 100

Preparing Stock Solutions

The following data is based on the product molecular weight 263.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.8 mL 18.99 mL 37.99 mL
5 mM 0.76 mL 3.8 mL 7.6 mL
10 mM 0.38 mL 1.9 mL 3.8 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

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References

References are publications that support the biological activity of the product.

Kojima et al (2014) Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain. Eur.J.Pharmacol. 723 288 PMID: 24291101


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Citations for ASP 7663

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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.