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Description: Potent and selective TRPA1 channel activator
Chemical Name: 2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide
Purity: ≥98% (HPLC)
Reviews (1)
Literature (2)

Biological Activity for JT010

JT010 is a potent and selective TRPA1 channel activator (EC50 = 0.65 nM); activates the TRPA1 channel by covalently and site-selectively binding to Cys621. Exhibits selectivity for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50 values are >1 μM).

Technical Data for JT010

M. Wt 354.85
Formula C16H19ClN2O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 917562-33-5
PubChem ID 18524489
Smiles O=C(N(CCCOC)C1=NC(C2=CC=C(OC)C=C2)=CS1)CCl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JT010

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.48 100
ethanol 17.74 50

Preparing Stock Solutions for JT010

The following data is based on the product molecular weight 354.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.09 mL 28.18 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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References for JT010

References are publications that support the biological activity of the product.

Takaya et al (2015) A potent and site-selective agonist of TRPA1. J.Am.Chem.Soc. 137 15859 PMID: 26630251

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Keywords: JT010, JT010 supplier, transient, receptor, potential, ankyrin, 1, selective, TRPA1, activators, activates, agonists, antagonism, potent, 6269, Tocris Bioscience

Citations for JT010

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Reviews for JT010

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An excellent TRPA1 channel activator.
By Zili Xie on 02/03/2019
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: HEK293

300 nM JT010 evoked Calcium responses in HEK293 cells transfected with recombinant TRPA1.

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Literature in this Area

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