JT010

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Cat.No. 6269 - JT010 | C16H19ClN2O3S | CAS No. 917562-33-5
Description: Potent and selective TRPA1 channel activator
Chemical Name: 2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective TRPA1 channel activator (EC50 = 65 nM); activates the TRPA1 channel by covalently and site-selectively binding to Cys621. Exhibits selectivity for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50 values are >1 μM).

Technical Data

M. Wt 354.85
Formula C16H19ClN2O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 917562-33-5
PubChem ID 18524489
InChI Key KZMAWJRXKGLWGS-UHFFFAOYSA-N
Smiles O=C(N(CCCOC)C1=NC(C2=CC=C(OC)C=C2)=CS1)CCl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.48 100
ethanol 17.74 50

Preparing Stock Solutions

The following data is based on the product molecular weight 354.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.09 mL 28.18 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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References

References are publications that support the biological activity of the product.

Takaya et al (2015) A potent and site-selective agonist of TRPA1. J.Am.Chem.Soc. 137 15859 PMID: 26630251


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