You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for JT010
JT010 is a potent and selective TRPA1 channel activator (EC50 = 0.65 nM); activates the TRPA1 channel by covalently and site-selectively binding to Cys621. Exhibits selectivity for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50 values are >1 μM).
Technical Data for JT010
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for JT010
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for JT010
The following data is based on the product molecular weight 354.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.82 mL||14.09 mL||28.18 mL|
|5 mM||0.56 mL||2.82 mL||5.64 mL|
|10 mM||0.28 mL||1.41 mL||2.82 mL|
|50 mM||0.06 mL||0.28 mL||0.56 mL|
References for JT010
References are publications that support the biological activity of the product.
Takaya et al (2015) A potent and site-selective agonist of TRPA1. J.Am.Chem.Soc. 137 15859 PMID: 26630251
If you know of a relevant reference for JT010, please let us know.
View Related Products by Product Action
Keywords: JT010, JT010 supplier, transient, receptor, potential, ankyrin, 1, selective, TRPA1, activators, activates, agonists, antagonism, potent, 6269, Tocris Bioscience
1 Citation for JT010
Citations are publications that use Tocris products. Selected citations for JT010 include:
Emmanouil et al (2022) Derivation of nociceptive sensory neurons from hiPSCs with early patterning and temporally controlled NEUROG2 overexpression. Cell Rep Methods 2 100341 PMID: 36452863
Do you know of a great paper that uses JT010 from Tocris? Please let us know.
Reviews for JT010
Average Rating: 5 (Based on 1 Review.)
Have you used JT010?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image