A 967079

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Cat.No. 4716 - A 967079 | C12H14FNO | CAS No. 1170613-55-4
Description: Selective TRPA1 channel blocker
Chemical Name: (1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime
Purity: ≥98% (HPLC)
Citations (7)
Reviews (1)
Literature (2)

Biological Activity

Selective TRPA1 channel blocker (IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively). Displays 1000-fold selectivity for TRPA1 over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes and G-protein-coupled receptors. Exhibits analgesic effects in a rat osteoarthritic pain model.

Compound Libraries

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Technical Data

M. Wt 207.24
Formula C12H14FNO
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1170613-55-4
PubChem ID 42641861
Smiles FC1=CC=C(/C=C(C)/C(CC)=N/O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.72 100
ethanol 20.72 100

Preparing Stock Solutions

The following data is based on the product molecular weight 207.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.83 mL 24.13 mL 48.25 mL
5 mM 0.97 mL 4.83 mL 9.65 mL
10 mM 0.48 mL 2.41 mL 4.83 mL
50 mM 0.1 mL 0.48 mL 0.97 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

McGaraughty et al (2010) TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats. Mol.Pain 6 14 PMID: 20205719

Chen et al (2011) Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation. Pain 152 1165 PMID: 21402443

If you know of a relevant reference for A 967079, please let us know.

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Keywords: A 967079, A 967079 supplier, A967079, TRPA1, blockers, selective, TRP, channels, transient, receptor, potential, 4716, Tocris Bioscience

7 Citations for A 967079

Citations are publications that use Tocris products. Selected citations for A 967079 include:

Zhao et al (2020) Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Nature PMID: 32641835

Cheng et al (2019) The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes. Theranostics 9 4287 PMID: 31285762

Jiang et al (2019) ROS/TRPA1/CGRP signaling mediates cortical spreading depression. J Headache Pain 20 25 PMID: 30841847

Paulsen et al (2015) Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature 520 511 PMID: 25855297

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Reviews for A 967079

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Blocking TRPA1 function in chronic itch.
By Jing Feng on 01/04/2018
Assay Type: In Vivo
Species: Mouse

A967079 was used in the animal behavior test to block the TRPA1-mediated chronic itch at the concentration of 10mg/Kg

It may be a little difficult to dissolve the drug at a higher concentration.

PMID: 29081531
review image

Literature in this Area

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Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.