A 967079

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Description: Selective TRPA1 channel blocker
Alternative Names: A-079
Chemical Name: (1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime
Purity: ≥98% (HPLC)
Citations (12)
Reviews (1)

Biological Activity for A 967079

A 967079 (also known as A-079) is a selective TRPA1 channel blocker (IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively) that displays 1000-fold selectivity for TRPA1 over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes and G-protein-coupled receptors. A 967079 exhibits analgesic effects in a rat osteoarthritic pain model.

External Portal Information for A 967079

The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of A 967079 (A-079) is reviewed.

Compound Libraries for A 967079

A 967079 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for A 967079

M. Wt 207.24
Formula C12H14FNO
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1170613-55-4
PubChem ID 42641861
Smiles FC1=CC=C(/C=C(C)/C(CC)=N/O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for A 967079

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.72 100
ethanol 20.72 100

Preparing Stock Solutions for A 967079

The following data is based on the product molecular weight 207.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.83 mL 24.13 mL 48.25 mL
5 mM 0.97 mL 4.83 mL 9.65 mL
10 mM 0.48 mL 2.41 mL 4.83 mL
50 mM 0.1 mL 0.48 mL 0.97 mL

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Product Datasheets for A 967079

Certificate of Analysis / Product Datasheet
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References for A 967079

References are publications that support the biological activity of the product.

McGaraughty et al (2010) TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats. Mol.Pain 6 14 PMID: 20205719

Chen et al (2011) Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation. Pain 152 1165 PMID: 21402443

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Keywords: A 967079, A 967079 supplier, A967079, TRPA1, blockers, selective, TRP, channels, transient, receptor, potential, A-079, 4716, Tocris Bioscience

12 Citations for A 967079

Citations are publications that use Tocris products. Selected citations for A 967079 include:

Paulsen et al (2015) Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature 520 511 PMID: 25855297

Tong et al (2022) The Role of Transient Receptor Potential A1 and G Protein-Coupled Receptor 39 in Zinc-Mediated Acute and Chronic Itch in Mice. Front Mol Neurosci 14 768731 PMID: 35095413

Ko et al (2019) A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery. Sci Rep 9 2430 PMID: 30787340

Wu et al (2017) Ethyl Vanillin Activates TRPA1. J Pharmacol Exp Ther 362 368 PMID: 28620120

Do you know of a great paper that uses A 967079 from Tocris? Please let us know.

Reviews for A 967079

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Blocking TRPA1 function in chronic itch.
By Jing Feng on 01/04/2018
Assay Type: In Vivo
Species: Mouse

A967079 was used in the animal behavior test to block the TRPA1-mediated chronic itch at the concentration of 10mg/Kg

It may be a little difficult to dissolve the drug at a higher concentration.

PMID: 29081531
review image