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Biological Activity for AP 18
AP 18 is a reversible TRPA1 channel blocker (IC50 values are 3.1 and 4.5 μM at human and mouse TRPA1 respectively). Blocks cinnamaldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo. Also blocks TRPA1 pore dilation (IC50 = 10.3 μM for the inhibition of Yo-Pro uptake).
Compound Libraries for AP 18
Technical Data for AP 18
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AP 18
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AP 18
The following data is based on the product molecular weight 209.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.77 mL||23.85 mL||47.69 mL|
|5 mM||0.95 mL||4.77 mL||9.54 mL|
|10 mM||0.48 mL||2.38 mL||4.77 mL|
|50 mM||0.1 mL||0.48 mL||0.95 mL|
References for AP 18
References are publications that support the biological activity of the product.
Petrus et al (2007) A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol.Pain 3 40 PMID: 18086313
Chen et al (2009) Pore dilation occurs in TRPA1 but not in TRPM8 channels. Mol.Pain 5 3 PMID: 19159452
Taylor-Clark et al (2009) Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1. Mol.Pharmacol. 75 820 PMID: 19171673
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Keywords: AP 18, AP 18 supplier, Reversible, TRPA1, channel, blockers, Channels, Transient, Receptor, Potential, AP18, 3296, Tocris Bioscience
2 Citations for AP 18
Citations are publications that use Tocris products. Selected citations for AP 18 include:
Izzo et al (2012) Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. Br J Pharmacol 166 1444 PMID: 22300105
Capasso et al (2012) Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects. Br J Pharmacol 165 1966 PMID: 21955242
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.