You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for BCI
BCI is an allosteric inhibitor of dual specificity phosphatase DUSP6 and DUSP1 (EC50 values are 8.0 μM and 13.3 μM respectively). Increases P2X7 receptor expression in neuroblastoma cells, reduces cell viability of EGFR or KRAS mutant lung cancer cells, and induces apoptosis in p53-null non-small cell lung cancer cells. In an animal model of myocardial infarction, BCI improves heart function, reduces fibrosis, and reduces inflammation by inhibiting macrophage formation. Activates FGF signaling in zebrafish embryo development to increase myocardial progenitor population and heart size.
Technical Data for BCI
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BCI
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for BCI
The following data is based on the product molecular weight 317.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.15 mL||15.75 mL||31.5 mL|
|5 mM||0.63 mL||3.15 mL||6.3 mL|
|10 mM||0.32 mL||1.58 mL||3.15 mL|
|50 mM||0.06 mL||0.32 mL||0.63 mL|
References for BCI
References are publications that support the biological activity of the product.
Zhang et al (2023) A DUSP6 inhibitor suppresses inflammatory cardiac remodeling and improves heart function after myocardial infarction. Dis.Model.Mech. 16 dmm049662 PMID: 36478044
Shin et al (2018) BCI induces apoptosis via generation of reactive oxygen species and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells. Sci.China Life Sci. 61 1243 PMID: 29524123
Benito-León et al (2022) BCI, an inhibitor of the DUSP1 and DUSP6 dual specificity phosphatases, enhances P2X7 receptor expression in neuroblastoma cells. Front.Cell Dev.Biol. 15 1049566 PMID: 36589747
Unni et al (2018) Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells. eLife 7 e33718 PMID: 30475204
If you know of a relevant reference for BCI, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: BCI, BCI supplier, dual, specificity, phosphatase, DUSP1, DUSP6, P2X7, receptor, neuroblastoma, EGFR, KRAS, lung, cancer, NSCLC, apoptosis, FGF, signaling, myocardial, progenitor, macrophage, anti-inflammatory, heart, MI, infarction, p53, allosteric, inhibitors, inhibits, Protein, Tyrosine, Phosphatases, Other, MAPK, 7481, Tocris Bioscience
Citations for BCI
Citations are publications that use Tocris products.
Currently there are no citations for BCI. Do you know of a great paper that uses BCI from Tocris? Please let us know.
Reviews for BCI
There are currently no reviews for this product. Be the first to review BCI and earn rewards!
Have you used BCI?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.