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Description: Potent PTEN inhibitor
Chemical Name: (OC-6-45)-Aqua(3-hydroxy-2-pyridinecarboxylato-κ-N1,κO2)[3-(hydroxy-κO)-2-pyridinecarboxylato(2-)-κO2]oxovanadate(1-),hydrogen
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for VO-OHpic

VO-OHpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) (IC50 = 35 nM). Displays selectivity for PTEN over cysteine-based phosphatases such as SopB, MTM, PTPβ and SAC (IC50 values are 588 nM, 4.03, 57.5 and >10 μM respectively). Increases PIP2 and PIP3 levels; also increases Akt translocation in NIH/3T3 fibroblasts. Blocks the immunosuppressant activity of IDO-activated Tregs. Promotes antitumor inflammatory response in combination with immunotherapy and enhances anticancer chemotherapy in tumor-bearing mice.

Technical Data for VO-OHpic

M. Wt 361.16
Formula C12H10N2O8V
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 675848-25-6
PubChem ID 90488861
Smiles OC1=C2C([O-][V+2]3(O)([O-]C(C4=NC=CC=C4[O-]3)=O)([N]2=CC=C1)=O)=O.[H+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for VO-OHpic

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.12 100

Preparing Stock Solutions for VO-OHpic

The following data is based on the product molecular weight 361.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.84 mL 27.69 mL
5 mM 0.55 mL 2.77 mL 5.54 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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References for VO-OHpic

References are publications that support the biological activity of the product.

Rosivatz et al (2006) A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem.Biol. 1 780 PMID: 17240976

Sharma et al (2015) The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Sci.Adv. 1 e1500845 PMID: 26601142

If you know of a relevant reference for VO-OHpic, please let us know.

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Keywords: VO-OHpic, VO-OHpic supplier, 476310-60-08, potent, inhibitors, inhibits, PTEN, phosphate, tensin, homolog, deleted, chromosome, 10, Protein, Tyrosine, Phosphatases, 3591, Tocris Bioscience

1 Citation for VO-OHpic

Citations are publications that use Tocris products. Selected citations for VO-OHpic include:

Justyna et al (2022) Cell Culture Media, Unlike the Presence of Insulin, Affect α-Synuclein Aggregation in Dopaminergic Neurons. Biomolecules 12 PMID: 35454152

Do you know of a great paper that uses VO-OHpic from Tocris? Please let us know.

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