Sodium orthovanadate

Pricing Availability   Qty
Description: Protein tyrosine phosphatase inhibitor
Chemical Name: Trisodium vanadate

Biological Activity for Sodium orthovanadate

Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and ATPases. Suppresses p53-mediated apoptosis by transcription-dependent and -independent pathways.

Technical Data for Sodium orthovanadate

M. Wt 183.91
Formula Na3O4V
Storage Store at RT
CAS Number 13721-39-6
PubChem ID 61671
Smiles O=[V]([O-])([O-])[O-].[Na+].[Na+].[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Sodium orthovanadate

Solvent Max Conc. mg/mL Max Conc. mM
water 18.39 100

Preparing Stock Solutions for Sodium orthovanadate

The following data is based on the product molecular weight 183.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.44 mL 27.19 mL 54.37 mL
5 mM 1.09 mL 5.44 mL 10.87 mL
10 mM 0.54 mL 2.72 mL 5.44 mL
50 mM 0.11 mL 0.54 mL 1.09 mL

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Product Datasheets for Sodium orthovanadate

References for Sodium orthovanadate

References are publications that support the biological activity of the product.

Ai et al (2004) Inhibition of small-intestinal sugar absorption mediated by sodium orthovanadate Na3VO4 in rats and its mechanisms. World J.Gastroenterol. 10 3612 PMID: 15534916

Hasegawa et al (2006) Therapeutic time window and dose dependence of neuroprotective effects of sodium orthovanadate following transient middle cerebral artery occlusion in rats. J.Pharmacol.Exp.Ther. 317 875 PMID: 16461588

Matsumoto et al (2006) Sodium orthovanadate enhances proliferation of progenitor cells in the adult rat subventricular zone after focal cerebral ischemia. J.Pharmacol.Exp.Ther. 318 982 PMID: 16782823

Morita et al (2010) Sodium orthovanadate inhibits p53-mediated apoptosis. Cancer Res. 70 257 PMID: 20048077

If you know of a relevant reference for Sodium orthovanadate, please let us know.

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Citations for Sodium orthovanadate

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