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Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and ATPases. Suppresses p53-mediated apoptosis by transcription-dependent and -independent pathways.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 183.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.44 mL||27.19 mL||54.37 mL|
|5 mM||1.09 mL||5.44 mL||10.87 mL|
|10 mM||0.54 mL||2.72 mL||5.44 mL|
|50 mM||0.11 mL||0.54 mL||1.09 mL|
References are publications that support the biological activity of the product.
Ai et al (2004) Inhibition of small-intestinal sugar absorption mediated by sodium orthovanadate Na3VO4 in rats and its mechanisms. World J.Gastroenterol. 10 3612 PMID: 15534916
Hasegawa et al (2006) Therapeutic time window and dose dependence of neuroprotective effects of sodium orthovanadate following transient middle cerebral artery occlusion in rats. J.Pharmacol.Exp.Ther. 317 875 PMID: 16461588
Matsumoto et al (2006) Sodium orthovanadate enhances proliferation of progenitor cells in the adult rat subventricular zone after focal cerebral ischemia. J.Pharmacol.Exp.Ther. 318 982 PMID: 16782823
Morita et al (2010) Sodium orthovanadate inhibits p53-mediated apoptosis. Cancer Res. 70 257 PMID: 20048077
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Keywords: Sodium orthovanadate, Sodium orthovanadate supplier, Protein, tyrosine, phosphatase, inhibitors, PTP, Shp1, Shp2, Tyrosine, Phosphatases, inhibits, ATPases, inhibitor, alkaline, phosphatases, Other, 2821, Tocris Bioscience
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