Sodium orthovanadate

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Cat.No. 2821 - Sodium orthovanadate | Na3O4V | CAS No. 13721-39-6
Description: Protein tyrosine phosphatase inhibitor
Chemical Name: Trisodium vanadate
Datasheet
Citations
Literature

Biological Activity

Inhibitor of protein tyrosine phosphatases, alkaline phosphatases and ATPases. Suppresses p53-mediated apoptosis by transcription-dependent and -independent pathways.

Technical Data

M. Wt 183.91
Formula Na3O4V
Storage Store at RT
CAS Number 13721-39-6
PubChem ID 61671
InChI Key IHIXIJGXTJIKRB-UHFFFAOYSA-N
Smiles O=[V]([O-])([O-])[O-].[Na+].[Na+].[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 18.39 100

Preparing Stock Solutions

The following data is based on the product molecular weight 183.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.44 mL 27.19 mL 54.37 mL
5 mM 1.09 mL 5.44 mL 10.87 mL
10 mM 0.54 mL 2.72 mL 5.44 mL
50 mM 0.11 mL 0.54 mL 1.09 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ai et al (2004) Inhibition of small-intestinal sugar absorption mediated by sodium orthovanadate Na3VO4 in rats and its mechanisms. World J.Gastroenterol. 10 3612 PMID: 15534916

Hasegawa et al (2006) Therapeutic time window and dose dependence of neuroprotective effects of sodium orthovanadate following transient middle cerebral artery occlusion in rats. J.Pharmacol.Exp.Ther. 317 875 PMID: 16461588

Matsumoto et al (2006) Sodium orthovanadate enhances proliferation of progenitor cells in the adult rat subventricular zone after focal cerebral ischemia. J.Pharmacol.Exp.Ther. 318 982 PMID: 16782823

Morita et al (2010) Sodium orthovanadate inhibits p53-mediated apoptosis. Cancer Res. 70 257 PMID: 20048077


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Citations for Sodium orthovanadate

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
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Pathways for Sodium orthovanadate

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