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Biological Activity for CX08005
CX08005 is a competitive PTP1B inhibitor (IC50 = 0.781 μM). Binds catalytic P-loop of enzyme. Improves insulin sensitivity in obese mice in the glucose tolerance test and the homeostasis model assessment of insulin resistance index (HOMA-IR). Enhances insulin-induced glucose uptake in adipocytes and myotubes in vitro. Exhibits some selectivity for PTP1B over other protein tyrosine phosphatases, except TCPTP.
Technical Data for CX08005
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CX08005
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CX08005
The following data is based on the product molecular weight 453.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.2 mL||11.02 mL||22.05 mL|
|5 mM||0.44 mL||2.2 mL||4.41 mL|
|10 mM||0.22 mL||1.1 mL||2.2 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References for CX08005
References are publications that support the biological activity of the product.
Zhang et al (2016) A novel protein tyrosine phosphatase 1B inhibitor with therapeutic potential for Ins resistance. Br.J.Pharmacol. 173 1939 PMID: 26990621
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Keywords: CX08005, CX08005 supplier, PTP1B, inhibitors, inhibits, protein, tyrosine, phosphatases, T2DM, diabetes, insulin, sensitivity, Protein, Tyrosine, Phosphatases, 6144, Tocris Bioscience
Citations for CX08005
Citations are publications that use Tocris products.
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Literature in this Area
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