Competitive PTP1B inhibitor (IC50 = 0.781 μM). Binds catalytic P-loop of enzyme. Improves insulin sensitivity in obese mice in the glucose tolerance test and the homeostasis model assessment of insulin resistance index (HOMA-IR). Enhances insulin-induced glucose uptake in adipocytes and myotubes in vitro. Exhibits some selectivity for PTP1B over other protein tyrosine phosphatases, except TCPTP.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 453.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.2 mL||11.02 mL||22.05 mL|
|5 mM||0.44 mL||2.2 mL||4.41 mL|
|10 mM||0.22 mL||1.1 mL||2.2 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References are publications that support the biological activity of the product.
Zhang et al (2016) A novel protein tyrosine phosphatase 1B inhibitor with therapeutic potential for insulin resistance. Br.J.Pharmacol. 173 1939 PMID: 26990621
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Keywords: CX08005, CX08005 supplier, PTP1B, inhibitors, inhibits, protein, tyrosine, phosphatases, T2DM, diabetes, insulin, sensitivity, Protein, Tyrosine, Phosphatases, 6144, Tocris Bioscience
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