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Description: Competitive PTP1B inhibitor
Chemical Name: 2-[[[2-(Tetradecyl)phenyl]amino]carbonyl]benzoic acid
Purity: ≥98% (HPLC)

Biological Activity for CX08005

CX08005 is a competitive PTP1B inhibitor (IC50 = 0.781 μM). Binds catalytic P-loop of enzyme. Improves insulin sensitivity in obese mice in the glucose tolerance test and the homeostasis model assessment of insulin resistance index (HOMA-IR). Enhances insulin-induced glucose uptake in adipocytes and myotubes in vitro. Exhibits some selectivity for PTP1B over other protein tyrosine phosphatases, except TCPTP.

Technical Data for CX08005

M. Wt 453.61
Formula C28H39N04
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1256341-22-6
PubChem ID 51001376

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CX08005

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 45.36 100
ethanol 45.36 100

Preparing Stock Solutions for CX08005

The following data is based on the product molecular weight 453.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 11.02 mL 22.05 mL
5 mM 0.44 mL 2.2 mL 4.41 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References for CX08005

References are publications that support the biological activity of the product.

Zhang et al (2016) A novel protein tyrosine phosphatase 1B inhibitor with therapeutic potential for Ins resistance. Br.J.Pharmacol. 173 1939 PMID: 26990621

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Citations for CX08005

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