Pricing Availability   Qty
Description: Lipid mediator, anorexic actions; also GPR55 and PPARα agonist
Chemical Name: (9Z)-N-(2-Hydroxyethyl)-9-octadecenamide
Purity: ≥99% (HPLC)
Citations (4)

Biological Activity for Oleylethanolamide

Oleylethanolamide is a lipid mediator and analog of anandamide (Cat. No. 1339) that is involved in peripheral regulation of feeding. Selective GPR55 agonist (EC50 values are 0.44, >30 and >30 μM at GPR55, CB1 and CB2 respectively) and PPARα agonist (EC50 = 120 nM). Induces satiety through activation of PPARα and is also a ceramidase inhibitor. Also endogenous agonist at the GPR119 receptor.

Technical Data for Oleylethanolamide

M. Wt 325.53
Formula C20H39NO2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 111-58-0
PubChem ID 5283454

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Oleylethanolamide

Certificate of Analysis / Product Datasheet
Select another batch:

References for Oleylethanolamide

References are publications that support the biological activity of the product.

Calignano et al (2001) Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide. Eur.J.Pharmacol. 419 191 PMID: 11426841

Coroneos et al (1995) Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. J.Biol.Chem. 270 23305 PMID: 7559485

de Fonseca et al (2001) An anorexic lipid mediator regulated by feeding. Nature 414 209 PMID: 11700558

Fu et al (2003) Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α. Nature 425 90 PMID: 12955147

Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302

If you know of a relevant reference for Oleylethanolamide, please let us know.

Keywords: Oleylethanolamide, Oleylethanolamide supplier, Lipid, mediator, anorexic, actions, GPR55, PPARα, PPARalpha, agonists, Ceramidase, inhibitors, inhibits, Endogenous, GPR119, receptor, Peroxisome, Proliferator-activating, Receptors, PPAR, Cannabinoids, Ceramidases, Other, Metabolism, 1484, Tocris Bioscience

4 Citations for Oleylethanolamide

Citations are publications that use Tocris products. Selected citations for Oleylethanolamide include:

Suárez et al (2014) Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech 7 129 PMID: 24159189

Ropero et al (2009) Rapid non-genomic regulation of Ca2+ signals and Ins secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans. J Endocrinol 200 127 PMID: 19017711

Silva-Peña et al (2019) Oleoylethanolamide Modulates BDNF-ERK Signaling and Neurogenesis in the Hippocampi of Rats Exposed to δ9-THC and Ethanol Binge Drinking During Adolescence. Front Mol Neurosci 12 96 PMID: 31068789

Ho et al (2008) 'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors. Br J Pharmacol 155 837 PMID: 18695637

Do you know of a great paper that uses Oleylethanolamide from Tocris? Please let us know.

Reviews for Oleylethanolamide

There are currently no reviews for this product. Be the first to review Oleylethanolamide and earn rewards!

Have you used Oleylethanolamide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review