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Submit ReviewWY 14643
Description: Selective PPARα agonist
Chemical Name: [[4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetic acid
Purity: ≥98% (HPLC)
Biological Activity for WY 14643
WY 14643 is a selective PPARα agonist (EC50 values are 0.63, 32 and > 100 μM at PPARα, PPARγ and PPARδ respectively). Negatively inhibits NF-κB transcriptional activity and decreases the inflammatory response in vitro and in vivo.
Compound Libraries for WY 14643
WY 14643 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for WY 14643
| M. Wt | 323.8 |
| Formula | C14H14ClN3O2S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 50892-23-4 |
| PubChem ID | 5694 |
| InChI Key | SZRPDCCEHVWOJX-UHFFFAOYSA-N |
| Smiles | CC1=C(C)C(NC2=CC(Cl)=NC(SCC(O)=O)=N2)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for WY 14643
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.38 | 100 |
Preparing Stock Solutions for WY 14643
The following data is based on the product molecular weight 323.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.09 mL | 15.44 mL | 30.88 mL |
| 5 mM | 0.62 mL | 3.09 mL | 6.18 mL |
| 10 mM | 0.31 mL | 1.54 mL | 3.09 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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Product Datasheets for WY 14643
References for WY 14643
References are publications that support the biological activity of the product.
Bishop-Bailey (2000) Peroxisome proliferator-activated receptors in the cardiovascular system. Br.J.Pharmacol. 129 823 PMID: 10696077
Forman et al (1997) Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc.Natl.Acad.Sci.U.S.A. 94 4312 PMID: 9113986
Willson et al (2000) The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 43 527 PMID: 10691680
If you know of a relevant reference for WY 14643, please let us know.
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Keywords: WY 14643, WY 14643 supplier, Selective, PPARα, PPARalpha, agonists, Peroxisome-Proliferator, Receptors, PPARs, WY14643, 1312, Tocris Bioscience
12 Citations for WY 14643
Citations are publications that use Tocris products. Selected citations for WY 14643 include:
Oruqaj et al (2015) Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling. Proc Natl Acad Sci U S A 112 E2048 PMID: 25848047
Mascia et al (2011) Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Biol Psychiatry 69 633 PMID: 20801430
Melis et al (2008) Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic DA neurons through nuclear receptors. J Neurosci 28 13985 PMID: 19091987
Neuhaus et al (2017) Multifaceted Mechanisms of WY-14643 to Stabilize the Blood-Brain Barrier in a Model of Traumatic Brain Injury. Front Mol Neurosci 10 149 PMID: 28603485
Strand et al (2019) Short-Term Activation of Peroxisome Proliferator-Activated Receptors α and γ Induces Tissue-Specific Effects on Lipid Metabolism and Fatty Acid Composition in Male Wistar Rats. PPAR Res 2019 8047627 PMID: 31308847
Smith et al (2019) Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties. Psychopharmacology (Berl) PMID: 31119329
Puligheddu et al (2013) PPAR-alpha agonists as novel antiepileptic drugs: preclinical findings. PLoS One 8 e64541 PMID: 23724059
Lee et al (2018) Peroxisome Proliferator-Activated Receptor α Agonist and Its Target Nanog Cooperate to Induce Pluripotency. J Clin Med 7 PMID: 30486372
Lee et al (2004) Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level. Biochem J 378 983 PMID: 14641110
Ropero et al (2009) Rapid non-genomic regulation of Ca2+ signals and Ins secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans. J Endocrinol 200 127 PMID: 19017711
Rizvi et al (2013) Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis. Vascul Pharmacol 59 144 PMID: 24050945
Bumpus and Johnson (2011) 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated Mol Psychiatry 339 886 PMID: 21896918
Do you know of a great paper that uses WY 14643 from Tocris? Please let us know.
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