WY 14643

Pricing Availability Delivery Time Qty
Cat.No. 1312 - WY 14643 | C14H14ClN3O2S | CAS No. 50892-23-4
Description: Selective PPARα agonist
Chemical Name: [[4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Literature

Biological Activity

Selective PPARα agonist (EC50 values are 0.63, 32 and > 100 μM at PPARα, PPARγ and PPARδ respectively). Negatively inhibits NF-κB transcriptional activity and decreases the inflammatory response in vitro and in vivo.

Compound Libraries

WY 14643 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 323.8
Formula C14H14ClN3O2S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 50892-23-4
PubChem ID 5694
InChI Key SZRPDCCEHVWOJX-UHFFFAOYSA-N
Smiles CC1=C(C)C(NC2=CC(Cl)=NC(SCC(O)=O)=N2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.38 100

Preparing Stock Solutions

The following data is based on the product molecular weight 323.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.09 mL 15.44 mL 30.88 mL
5 mM 0.62 mL 3.09 mL 6.18 mL
10 mM 0.31 mL 1.54 mL 3.09 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bishop-Bailey (2000) Peroxisome proliferator-activated receptors in the cardiovascular system. Br.J.Pharmacol. 129 823 PMID: 10696077

Forman et al (1997) Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc.Natl.Acad.Sci.U.S.A. 94 4312 PMID: 9113986

Willson et al (2000) The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 43 527 PMID: 10691680


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Keywords: Selective PPARα PPARalpha agonists Peroxisome-Proliferator Receptors PPARs WY14643 PPARalpha Receptors

6 Citations for WY 14643

Citations are publications that use Tocris products. Selected citations for WY 14643 include:

Oruqaj et al (2015) Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling. Proc Natl Acad Sci U S A 112 E2048 PMID: 25848047

Rizvi et al (2013) Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis. Vascul Pharmacol 59 144 PMID: 24050945

Mascia et al (2011) Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Biol Psychiatry 69 633 PMID: 20801430

Bumpus and Johnson (2011) 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated Mol Psychiatry 339 886 PMID: 21896918

Ropero et al (2009) Rapid non-genomic regulation of Ca2+ signals and insulin secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans. J Endocrinol 200 127 PMID: 19017711

Melis et al (2008) Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors. J Neurosci 28 13985 PMID: 19091987


Do you know of a great paper that uses WY 14643 from Tocris? If so please let us know.

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Literature in this Area

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Pathways for WY 14643

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