PDGFR
Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation.
PDGFR Inhibitors |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 5013 | AC 710 |
| Potent and selective PDGFR family inhibitor | |
| 4274 | AP 24534 |
| Potent multi-kinase and pan-Bcr-Abl inhibitor | |
| 7454 | Cediranib |
| Potent inhibitor of VEGFR, PDGFR and FGFR | |
| 5993 | CP 673451 |
| Potent and selective PDGFR inhibitor | |
| 1222 | DMPQ dihydrochloride |
| Potent, selective inhibitor of PDGFRβ | |
| 5906 | Imatinib mesylate |
| PDGFR inhibitor; also inhibits v-Abl tyrosine kinase and c-kit | |
| 6976 | JNJ 10198409 |
| Potent PDGFRα and PDGFRβ inhibitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases | |
| 5260 | KG 5 |
| PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor; antiangiogenic | |
| 7743 | Linifanib |
| Potent inhibitor of PDGFRβ, KDR, FLT3 and CSF-1R | |
| 7705 | Masitinib |
| PDGFR inhibitor | |
| 7049 | Nintedanib |
| Potent VEGFR, PDGFR and FGFR inhibitor | |
| 3785 | PD 166285 dihydrochloride |
| PDGFRβ, FGFR and Src inhibitor; also inhibits Wee1 | |
| 6814 | Sorafenib |
| PDGFR-β inhibitor; also inhibits Raf-1, VEGFR-2, VEGFR-3, Flt-3 and cKIT | |
| 3304 | SU 16f |
| Potent and selective PDGFRβ inhibitor | |
| 3335 | SU 6668 |
| PDGFR, VEGFR and FGFR inhibitor | |
| 3768 | Sunitinib malate |
| Potent VEGFR, PDGFRβ and KIT inhibitor | |
Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of some diseases, including cancer.
There are two isoforms of the PDGFR receptor; PDGFRα and PDGFRβ, which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI3K and PKCγ pathways.
External sources of pharmacological information for PDGFR :
Literature for PDGFR
Tocris offers the following scientific literature for PDGFR to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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Our Angiogenesis in Cancer poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.
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