PDGFR

Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation.

Products
Background
Literature (3)
Gene Data

Inhibitors

Cat. No. Product Name / Activity
5013 AC 710
Potent and selective PDGFR family inhibitor
0493 AG 18
EGFR/PDGFR-kinase inhibitor
4274 AP 24534
Potent multi-kinase and pan-Bcr-Abl inhibitor
5993 CP 673451
Potent and selective PDGFR inhibitor
1222 DMPQ dihydrochloride
Potent, selective inhibitor of PDGFRβ
6056 GSK 1363089
Potent PDGFR inhibtor; also inhibits of MET, VEGFR2, Ron and AXL
5906 Imatinib mesylate
PDGFR inhibitor; also inhibits v-Abl tyrosine kinase and c-kit
5260 KG 5
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor; antiangiogenic
3785 PD 166285 dihydrochloride
PDGFRβ, FGFR and Src inhibitor; also inhibits Wee1
6814 Sorafenib
PDGFR-β inhibitor; also inhibits Raf-1, VEGFR-2, VEGFR-3, Flt-3 and cKIT
3304 SU 16f
Potent and selective PDGFRβ inhibitor
3335 SU 6668
PDGFR, VEGFR and FGFR inhibitor
3768 Sunitinib malate
Potent VEGFR, PDGFRβ and KIT inhibitor
3909 Toceranib
Potent PDGFR and VEGFR inhibitor

Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of some diseases, including cancer.

There are two isoforms of the PDGFR receptor; PDGFRα and PDGFRβ, which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI3K and PKCγ pathways.

External sources of pharmacological information for PDGFR :

    Literature for PDGFR

    Tocris offers the following scientific literature for PDGFR to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis
    Kinases

    Kinases Product Listing

    A collection of over 400 products for kinase research, the listing includes inhibitors of:

    • Receptor Tyrosine Kinases
    • Protein Kinases A, C, D and G
    • PI-3 Kinase, Akt and mTOR
    • MAPK Signaling
    • Receptor Serine/Threonine Kinases
    Angiogenesis in Cancer

    Angiogenesis in Cancer Poster

    Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

    PDGFR Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    PDGFRα Human PDGFRA NM_006206 P16234
    Mouse Pdgfra NM_001083316 P26618
    Rat Pdgfra NM_012802 P20786
    PDGFRβ Human PDGFRB NM_002609 P09619
    Mouse Pdgfrb NM_008809 P05622
    Rat Pdgfrb NM_031525 Q003I6