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Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation.
|Cat No||Product Name / Activity|
|Potent and selective PDGFR family inhibitor|
|Potent multi-kinase and pan-Bcr-Abl inhibitor|
|Potent and selective PDGFR inhibitor|
|Potent, selective inhibitor of PDGFRβ|
|Potent PDGFR inhibtor; also inhibits of MET, VEGFR2, Ron and AXL|
|PDGFR inhibitor; also inhibits v-Abl tyrosine kinase and c-kit|
|PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor; antiangiogenic|
|3785||PD 166285 dihydrochloride|
|PDGFRβ, FGFR and Src inhibitor; also inhibits Wee1|
|Potent and selective PDGFRβ inhibitor|
|PDGFR, VEGFR and FGFR inhibitor|
|Potent VEGFR, PDGFRβ and KIT inhibitor|
|Potent PDGFR and VEGFR inhibitor|
Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of some diseases, including cancer.
There are two isoforms of the PDGFR receptor; PDGFRα and PDGFRβ, which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI3K and PKCγ pathways.