AC 710

Pricing Availability   Qty
Description: Potent and selective PDGFR family inhibitor
Chemical Name: N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide
Purity: ≥99% (HPLC)
Citations (1)
Literature (1)

Biological Activity for AC 710

AC 710 is a potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.

Compound Libraries for AC 710

AC 710 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AC 710

M. Wt 562.7
Formula C31H42N6O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1351522-04-7
PubChem ID 54760053
Smiles CC(C2)(C)N(CC)C(C)(C)CC2OC1=CC=C(C(NC3=CC=C(NC(NC4=NOC(C(C)(C)C)=C4)=O)C=C3)=O)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AC 710

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 11.25 20

Preparing Stock Solutions for AC 710

The following data is based on the product molecular weight 562.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 8.89 mL 44.43 mL 88.86 mL
1 mM 1.78 mL 8.89 mL 17.77 mL
2 mM 0.89 mL 4.44 mL 8.89 mL
10 mM 0.18 mL 0.89 mL 1.78 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for AC 710

References are publications that support the biological activity of the product.

Liu et al (2012) Discovery of AC710, a globally selective inhibitor of platelet-derived growth factor receptor-family kinases. ACS Med.Chem.Lett. 3 997 PMID: 24900421

If you know of a relevant reference for AC 710, please let us know.

View Related Products by Product Action

View all PDGFR Inhibitors

Keywords: AC 710, AC 710 supplier, AC710, potent, PDGFR, platelet, derived, growth, factor, receptors, family, inhibitors, inhibits, KIT, FLT3, PDGFRalpha, PDGFRa, PDGFRα, PDGFRbeta, PDGFRb, PDGFRβ, CSFR1, antitumor, arthritis, FMS-like, tyrosine, kinases, c-fms, M-CSFR, Other, RTKs, 5013, Tocris Bioscience

1 Citation for AC 710

Citations are publications that use Tocris products. Selected citations for AC 710 include:

Srinivasan (2018) Substrate stiffness modulates the multipotency of human neural crest derived ectomesenchymalstem cells via CD44 mediated PDGFR signaling. Biomaterials 167 153 PMID: 29571051

Do you know of a great paper that uses AC 710 from Tocris? Please let us know.

Reviews for AC 710

There are currently no reviews for this product. Be the first to review AC 710 and earn rewards!

Have you used AC 710?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.