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Biological Activity for AC 710
AC 710 is a potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.
Compound Libraries for AC 710
Technical Data for AC 710
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AC 710
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AC 710
The following data is based on the product molecular weight 562.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||8.89 mL||44.43 mL||88.86 mL|
|1 mM||1.78 mL||8.89 mL||17.77 mL|
|2 mM||0.89 mL||4.44 mL||8.89 mL|
|10 mM||0.18 mL||0.89 mL||1.78 mL|
References for AC 710
References are publications that support the biological activity of the product.
Liu et al (2012) Discovery of AC710, a globally selective inhibitor of platelet-derived growth factor receptor-family kinases. ACS Med.Chem.Lett. 3 997 PMID: 24900421
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1 Citation for AC 710
Citations are publications that use Tocris products. Selected citations for AC 710 include:
Srinivasan (2018) Substrate stiffness modulates the multipotency of human neural crest derived ectomesenchymalstem cells via CD44 mediated PDGFR signaling. Biomaterials 167 153 PMID: 29571051
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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