Pricing Availability   Qty
Description: Potent VEGFR, PDGFR and FGFR inhibitor
Chemical Name: Methyl (Z)-3-[[[4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene]-2-oxoindoline-6-carboxylate
Purity: ≥98% (HPLC)
Literature (1)
Pathways (1)

Biological Activity for Nintedanib

Nintedanib is a potent inhibitor of vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs) and fibroblast growth factor receptors (FGFRs) (IC50 values are 13 - 34 nM for VEGFR subtypes, 59 - 65 nM for PDGFR subtypes, 37 - 108 nM for FGFR subtypes). Also inhibits Flt-3, Lck, Lyn and Src (IC50 values are 25 - 200 nM). Inhibits proliferation in VEGF-stimulated endothelial cells, and PDGF-stimulated pericytes and vascular smooth muscle cells. Reduces vessel density and integrity, and inhibits tumor growth in a mouse tumor xenograft model.

Technical Data for Nintedanib

M. Wt 539.64
Formula C31H33N5O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 656247-17-5
PubChem ID 135423438
Smiles COC(=O)C1=CC=C2C(NC(=O)\C2=C(/NC2=CC=C(C=C2)N(C)C(=O)CN2CCN(C)CC2)C2=CC=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Nintedanib

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 1.08 2 with gentle warming

Preparing Stock Solutions for Nintedanib

The following data is based on the product molecular weight 539.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.02 mM 92.65 mL 463.27 mL 926.54 mL
0.1 mM 18.53 mL 92.65 mL 185.31 mL
0.2 mM 9.27 mL 46.33 mL 92.65 mL
1 mM 1.85 mL 9.27 mL 18.53 mL

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References for Nintedanib

References are publications that support the biological activity of the product.

Hilberg et al (2008) BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 68 4774 PMID: 18559524

If you know of a relevant reference for Nintedanib, please let us know.

View Related Products by Product Action

View all VEGFR Inhibitors

Keywords: Nintedanib, Nintedanib supplier, BIBF1120, angiokinase, inhibitors, inhibits, VEGFR, PDGFR, FGFR, potent, vascular, endothelial, growth, factor, platelet-derived, fibroblast, angiogenesis, VEGF, FGF, PDGF, 7049, Tocris Bioscience

Citations for Nintedanib

Citations are publications that use Tocris products.

Currently there are no citations for Nintedanib. Do you know of a great paper that uses Nintedanib from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for Nintedanib

VEGF Signaling Pathway

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.