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Biological Activity for Nintedanib
Nintedanib is a potent inhibitor of vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs) and fibroblast growth factor receptors (FGFRs) (IC50 values are 13 - 34 nM for VEGFR subtypes, 59 - 65 nM for PDGFR subtypes, 37 - 108 nM for FGFR subtypes). Also inhibits Flt-3, Lck, Lyn and Src (IC50 values are 25 - 200 nM). Inhibits proliferation in VEGF-stimulated endothelial cells, and PDGF-stimulated pericytes and vascular smooth muscle cells. Reduces vessel density and integrity, and inhibits tumor growth in a mouse tumor xenograft model.
Technical Data for Nintedanib
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Nintedanib
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||1.08||2 with gentle warming|
Preparing Stock Solutions for Nintedanib
The following data is based on the product molecular weight 539.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.02 mM||92.65 mL||463.27 mL||926.54 mL|
|0.1 mM||18.53 mL||92.65 mL||185.31 mL|
|0.2 mM||9.27 mL||46.33 mL||92.65 mL|
|1 mM||1.85 mL||9.27 mL||18.53 mL|
References for Nintedanib
References are publications that support the biological activity of the product.
Hilberg et al (2008) BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 68 4774 PMID: 18559524
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Citations for Nintedanib
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Literature in this Area
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