Nintedanib

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Cat.No. 7049 - Nintedanib | C31H33N5O4 | CAS No. 656247-17-5
Description: Potent VEGFR, PDGFR and FGFR inhibitor
Chemical Name: Methyl (Z)-3-[[[4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene]-2-oxoindoline-6-carboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Pathways (1)

Biological Activity

Potent inhibitor of vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs) and fibroblast growth factor receptors (FGFRs) (IC50 values are 13 - 34 nM for VEGFR subtypes, 59 - 65 nM for PDGFR subtypes, 37 - 108 nM for FGFR subtypes). Also inhibits Flt-3, Lck, Lyn and Src (IC50 values are 25 - 200 nM). Inhibits proliferation in VEGF-stimulated endothelial cells, and PDGF-stimulated pericytes and vascular smooth muscle cells. Reduces vessel density and integrity, and inhibits tumor growth in a mouse tumor xenograft model.

Technical Data

M. Wt 539.64
Formula C31H33N5O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 656247-17-5
PubChem ID 135423438
InChI Key XZXHXSATPCNXJR-ZIADKAODSA-N
Smiles COC(=O)C1=CC=C2C(NC(=O)\C2=C(/NC2=CC=C(C=C2)N(C)C(=O)CN2CCN(C)CC2)C2=CC=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.08 2 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 539.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.02 mM 92.65 mL 463.27 mL 926.54 mL
0.1 mM 18.53 mL 92.65 mL 185.31 mL
0.2 mM 9.27 mL 46.33 mL 92.65 mL
1 mM 1.85 mL 9.27 mL 18.53 mL

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References

References are publications that support the biological activity of the product.

Hilberg et al (2008) BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 68 4774 PMID: 18559524


If you know of a relevant reference for Nintedanib, please let us know.

View Related Products by Product Action

View all VEGFR Inhibitors

Keywords: Nintedanib, Nintedanib supplier, BIBF1120, angiokinase, inhibitors, inhibits, VEGFR, PDGFR, FGFR, potent, vascular, endothelial, growth, factor, platelet-derived, fibroblast, angiogenesis, VEGF, FGF, PDGF, BIBF, 1120, 7049, Tocris Bioscience

Citations for Nintedanib

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Angiogenesis in Cancer

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for Nintedanib

VEGF

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.