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Biological Activity for CP 673451
CP 673451 is a potent and selective PDGFR inhibitor (IC50 values are 1 and 10 nM for PDGFR-β and -α respectively). Selective for PDGFR kinase over a range of related kinases. Inhibits PDGFR-β phosphorylation in glioblastoma xenografts and PDGF-induced angiogenesis in mice.
External Portal Information for CP 673451
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP 673451 is reviewed on the Chemical Probes website.
Compound Libraries for CP 673451
Technical Data for CP 673451
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CP 673451
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CP 673451
The following data is based on the product molecular weight 417.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||11.98 mL||59.88 mL||119.76 mL|
|1 mM||2.4 mL||11.98 mL||23.95 mL|
|2 mM||1.2 mL||5.99 mL||11.98 mL|
|10 mM||0.24 mL||1.2 mL||2.4 mL|
References for CP 673451
References are publications that support the biological activity of the product.
Roberts et al (2005) Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451. Cancer Res. 65 957 PMID: 15705896
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1 Citation for CP 673451
Citations are publications that use Tocris products. Selected citations for CP 673451 include:
Stacey M et al (2021) A Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane. Cell Stem Cell 28 315-330.e5 PMID: 33181078
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Literature in this Area
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