Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
CP 673451 is a potent and selective PDGFR inhibitor (IC50 values are 1 and 10 nM for PDGFR-β and -α respectively). Selective for PDGFR kinase over a range of related kinases. Inhibits PDGFR-β phosphorylation in glioblastoma xenografts and PDGF-induced angiogenesis in mice.
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP 673451 is reviewed on the Chemical Probes website.
CP 673451 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 417.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||11.98 mL||59.88 mL||119.76 mL|
|1 mM||2.4 mL||11.98 mL||23.95 mL|
|2 mM||1.2 mL||5.99 mL||11.98 mL|
|10 mM||0.24 mL||1.2 mL||2.4 mL|
References are publications that support the biological activity of the product.
Roberts et al (2005) Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451. Cancer Res. 65 957 PMID: 15705896
If you know of a relevant reference for CP 673451, please let us know.
Keywords: CP 673451, CP 673451 supplier, CP673451, PDGFRβ, beta, inhibitors, inhibits, platelet, derived, growth, factor, receptor, potent, selective, PDGFR, 5993, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for CP 673451. Do you know of a great paper that uses CP 673451 from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review CP 673451 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.