CP 673451

Pricing Availability   Qty
Description: Potent and selective PDGFR inhibitor
Chemical Name: 1-[2-[5-(2-Methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for CP 673451

CP 673451 is a potent and selective PDGFR inhibitor (IC50 values are 1 and 10 nM for PDGFR-β and -α respectively). Selective for PDGFR kinase over a range of related kinases. Inhibits PDGFR-β phosphorylation in glioblastoma xenografts and PDGF-induced angiogenesis in mice.

External Portal Information for CP 673451

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP 673451 is reviewed on the Chemical Probes website.

Compound Libraries for CP 673451

CP 673451 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for CP 673451

M. Wt 417.5
Formula C24H27N5O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 343787-29-1
PubChem ID 10158940

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CP 673451

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 8.35 20

Preparing Stock Solutions for CP 673451

The following data is based on the product molecular weight 417.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.98 mL 59.88 mL 119.76 mL
1 mM 2.4 mL 11.98 mL 23.95 mL
2 mM 1.2 mL 5.99 mL 11.98 mL
10 mM 0.24 mL 1.2 mL 2.4 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for CP 673451

Certificate of Analysis / Product Datasheet
Select another batch:

References for CP 673451

References are publications that support the biological activity of the product.

Roberts et al (2005) Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451. Cancer Res. 65 957 PMID: 15705896

If you know of a relevant reference for CP 673451, please let us know.

View Related Products by Product Action

View all PDGFR Inhibitors

Keywords: CP 673451, CP 673451 supplier, CP673451, PDGFRβ, beta, inhibitors, inhibits, platelet, derived, growth, factor, receptor, potent, selective, PDGFR, 5993, Tocris Bioscience

1 Citation for CP 673451

Citations are publications that use Tocris products. Selected citations for CP 673451 include:

Stacey M et al (2021) A Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane. Cell Stem Cell 28 315-330.e5 PMID: 33181078

Do you know of a great paper that uses CP 673451 from Tocris? Please let us know.

Reviews for CP 673451

There are currently no reviews for this product. Be the first to review CP 673451 and earn rewards!

Have you used CP 673451?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.