CP 673451

Pricing Availability Delivery Time Qty
Cat.No. 5993 - CP 673451 | C24H27N5O2 | CAS No. 343787-29-1
Description: Potent and selective PDGFR inhibitor
Chemical Name: 1-[2-[5-(2-Methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective PDGFR inhibitor (IC50 values are 1 and 10 nM for PDGFR-α and β, resepctively). Selective for PDGFR kinase over a range of related kinases. Inibits PDGFR-β phosphorylation in glioblastoma xenografts and PDGF-induced angiogenesis in mice.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP 673451 is reviewed on the Chemical Probes website.

Technical Data

M. Wt 417.5
Formula C24H27N5O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 343787-29-1
PubChem ID 10158940
InChI Key DEEOXSOLTLIWMG-UHFFFAOYSA-N
Smiles COCCOC1=CC=C2N(C3=NC4=C(C=C3)C=CC=C4N5CCC(CC5)N)C=NC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 41.75 100
DMSO 41.75 100

Preparing Stock Solutions

The following data is based on the product molecular weight 417.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 11.98 mL 23.95 mL
5 mM 0.48 mL 2.4 mL 4.79 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Roberts et al (2005) Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451. Cancer Res. 65 957 PMID: 15705896


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View all PDGFR Inhibitors

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Citations for CP 673451

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