JAK Kinase

JAKs (or Janus kinases) are a family of tyrosine kinases that are associated with cytokine receptors. Upon receptor activation JAKs phosphorylate the transcription factors known as STATs and initiate the JAK-STAT signaling pathway. Four JAK family members have been identified.

Products
Background
Literature
Pathways
Gene Data

Inhibitors

Cat No Product Name / Activity
0414 AG 490
JAK2, JAK3 inhibitor. Also EGFR-kinase inhibitor
4580 Atiprimod dihydrochloride
JAK2 inhibitor
5617 AZD 1480
Potent and selective JAK2 inhibitor; antiangiogenic
4500 Cercosporamide
Potent Mnk2 inhibitor; also inhibits JAK3
4556 CP 690550 citrate
Potent JAK inhibitor
1571 Cucurbitacin I
Selective inhibitor of STAT3/JAK2 signaling
2291 1,2,3,4,5,6-Hexabromocyclohexane
Inhibits JAK2 autophosphorylation
3395 Lestaurtinib
JAK2, FLT3 and TrkA inhibitor; also inhibits AurA and AurB
4338 NSC 33994
JAK2 inhibitor
5818 NVP BSK 805
Potent JAK2 inhibitor; orally bioavailable
3035 SD 1008
JAK2/STAT3 signaling pathway inhibitor
4221 TCS 21311
Potent JAK3 inhibitor. Also inhibits GSK-3β and PKC
3115 WHI-P 154
JAK3 kinase inhibitor. Also inhibits EGFR
1367 ZM 39923 hydrochloride
Potent, selective JAK3 inhibitor
1366 ZM 449829
Potent, selective JAK3 inhibitor

JAKs (or Janus kinases) are a family of tyrosine kinases that are associated with cytokine receptors. Upon receptor activation JAKs phosphorylate the transcription factors known as STATs and initiate the JAK-STAT signaling pathway. Four JAK family members have been identified (JAK1, JAK2, JAK3 and Tyk2), which share a similar protein domain structure: a kinase domain, a regulatory 'pseudo'-kinase domain, a SH2 domain and a FERM domain.

The FERM domain of JAK family members mediates the association of JAK with other enzymes and cytokine receptors. The JAK Tyk2 associates with the IFN-1, IL-6, 10, 12, and 23 cytokine receptor families. JAK1 mediates signals from IFN-α,β,γ and IL-2, 6 receptors. JAK2 transduces signals from the single chain and IL-3 cytokine receptor families, and from the IFN-γ receptors. JAK3 associates with the IL-2 receptor γ-chain.

Recent research has highlighted a regulatory role for JAK2 in the phosphorylation of histone proteins. This key epigenetic modification results in changes in chromatin architecture and therefore gene expression.

Literature for JAK Kinase

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for JAK Kinase

JAK-STAT

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.

JAK Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
JAK1 Human JAK1 NM_002227 P23458
Mouse Jak1 NM_146145 P52332
Rat Jak1 NM_002227 P23458
JAK2 Human JAK2 NM_004972 O60674
Mouse Jak2 NM_008413 Q62120
Rat Jak2 NM_031514 Q62689
JAK3 Human JAK3 NM_000215 P52333
Mouse Jak3 NM_010589 Q62137
Rat Jak3 NM_012855 Q63272
Tyk2 Human TYK2 NM_003331 P29597
Mouse Tyk2 NM_018793 Q9R117
Rat Tyk2 XM_233741 XP_233741