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TC JL 37
Biological Activity for TC JL 37
TC JL 37 is a potent inhibitor of tyrosine kinase 2 (TYK2, Ki = 1.6 nM). Shows some selectivity for TYK2 over JAK1/2/3. Inhibits IFNγ production in vivo in mice. Orally bioavailable.
Compound Libraries for TC JL 37
Technical Data for TC JL 37
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TC JL 37
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TC JL 37
The following data is based on the product molecular weight 376.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.65 mL||13.27 mL||26.54 mL|
|5 mM||0.53 mL||2.65 mL||5.31 mL|
|10 mM||0.27 mL||1.33 mL||2.65 mL|
|50 mM||0.05 mL||0.27 mL||0.53 mL|
References for TC JL 37
References are publications that support the biological activity of the product.
Liang et al (2013) Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors. J.Med.Chem. 56 4521 PMID: 23668484
If you know of a relevant reference for TC JL 37, please let us know.
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Keywords: TC JL 37, TC JL 37 supplier, TCJL37, Tyrosine, kinase, 2, inhibitors, inhibits, TYK2, potent, orally, bioavailable, JAK, Kinase, 6125, Tocris Bioscience
Citations for TC JL 37
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Literature in this Area
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