TC JL 37

Pricing Availability Delivery Time Qty
Cat.No. 6125 - TC JL 37 | C17H11ClF2N4O2 | CAS No. 1258294-34-6
Description: Potent TYK2 inhibitor
Chemical Name: 2-Chloro-4-cyano-6-fluoro-N-[2-[[[(1R,2R)-2-fluorocyclopropyl]carbonyl]amino]-4-pyridinyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Potent inhibitor of tyrosine kinase 2 (TYK2, Ki = 1.6 nM). Shows some selectivity for TYK2 over JAK1/2/3. Inhibits IFNγ production in vivo in mice. Orally bioavailable.

Technical Data

M. Wt 376.74
Formula C17H11ClF2N4O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1258294-34-6
Smiles F[C@@H]1C[C@@H]1C(NC2=CC(NC(C3=C(C=C(C#N)C=C3F)Cl)=O)=CC=N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.67 100

Preparing Stock Solutions

The following data is based on the product molecular weight 376.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.27 mL 26.54 mL
5 mM 0.53 mL 2.65 mL 5.31 mL
10 mM 0.27 mL 1.33 mL 2.65 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Liang et al (2013) Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors. J.Med.Chem. 56 4521 PMID: 23668484


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Keywords: TC JL 37, supplier, TCJL37, Tyrosine, kinase, 2, inhibitors, inhibits, TYK2, potent, orally, bioavailable, JAK, Kinase, JAK, Kinase, Tocris Bioscience

Citations for TC JL 37

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cancer

Cancer Research Product Guide

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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Pathways for TC JL 37

JAK-STAT

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.