2-BFI hydrochloride

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Cat.No. 0348 - 2-BFI hydrochloride | C11H10N2O.HCl | CAS No. 89196-95-2
Description: Potent, selective I2 ligand. Putative agonist
Chemical Name: 2-(2-Benzofuranyl)-2-imidazoline hydrochloride
Datasheet
Citations (1)
Reviews
Literature (1)

Biological Activity

High affinity I2 ligand (Ki = 9.8 nM). Putative I2 agonist; potentiates morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.

Technical Data

M. Wt 222.67
Formula C11H10N2O.HCl
Storage Desiccate at RT
CAS Number 89196-95-2
PubChem ID 45073465
InChI Key RFNFFVDVGWOSNZ-UHFFFAOYSA-N
Smiles Cl.C1CN=C(N1)C1=CC2=CC=CC=C2O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100

Preparing Stock Solutions

The following data is based on the product molecular weight 222.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.49 mL 22.45 mL 44.91 mL
5 mM 0.9 mL 4.49 mL 8.98 mL
10 mM 0.45 mL 2.25 mL 4.49 mL
50 mM 0.09 mL 0.45 mL 0.9 mL

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References

References are publications that support the biological activity of the product.

Alemany et al (1997) Labelling of I2B-imidazoline receptors by [3H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) in rat brain and liver: characterization, regulation and relation to monoamine oxidase enzymes. Naunyn Schmiedebergs Arch.Pharmacol. 356 39 PMID: 9228188

MacInnes and Duty (2004) Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxyDA lesion of the nigrostriatal pathway. Br.J.Pharmacol. 143 952 PMID: 15545290

Sanchez-Blasquez et al (2000) Activation of I2-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br.J.Pharmacol. 130 146 PMID: 10781010


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Keywords: 2-BFI hydrochloride, 2-BFI hydrochloride supplier, Potent, selective, I2, ligand, Putative, agonists, Imidazoline, Receptors, 0348, Tocris Bioscience

1 Citation for 2-BFI hydrochloride

Citations are publications that use Tocris products. Selected citations for 2-BFI hydrochloride include:

Kim et al (2011) Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation. Brain Res 1384 110 PMID: 21315691


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Literature in this Area

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