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High affinity I2 ligand (Ki = 9.8 nM). Putative I2 agonist; potentiates morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 222.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.49 mL||22.45 mL||44.91 mL|
|5 mM||0.9 mL||4.49 mL||8.98 mL|
|10 mM||0.45 mL||2.25 mL||4.49 mL|
|50 mM||0.09 mL||0.45 mL||0.9 mL|
References are publications that support the biological activity of the product.
Alemany et al (1997) Labelling of I2B-imidazoline receptors by [3H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) in rat brain and liver: characterization, regulation and relation to monoamine oxidase enzymes. Naunyn Schmiedebergs Arch.Pharmacol. 356 39 PMID: 9228188
MacInnes and Duty (2004) Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxyDA lesion of the nigrostriatal pathway. Br.J.Pharmacol. 143 952 PMID: 15545290
Sanchez-Blasquez et al (2000) Activation of I2-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br.J.Pharmacol. 130 146 PMID: 10781010
If you know of a relevant reference for 2-BFI hydrochloride, please let us know.
Keywords: 2-BFI hydrochloride, 2-BFI hydrochloride supplier, Potent, selective, I2, ligand, Putative, agonists, Imidazoline, Receptors, 0348, Tocris Bioscience
1 Citation for 2-BFI hydrochloride
Citations are publications that use Tocris products. Selected citations for 2-BFI hydrochloride include:
Kim et al (2011) Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation. Brain Res 1384 110 PMID: 21315691
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