Hexokinases

Hexokinases catalyze the first essential step of glucose metabolism, the conversion of the substrate glucose into glucose-6-phosphate. This phosphorylation event directly couples extramitochondrial glycolysis to intramitochondrial oxidative phosphorylation.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
1646 Lonidamine
Mitochondrial hexokinase inhibitor

Substrates

Cat No Product Name / Activity
4515 2-Deoxy-D-glucose
Non-metabolizable glucose analog; hexokinase substrate

Activators

Cat No Product Name / Activity
6034 AM 2394
Potent glucokinase activator; orally bioavailable
5133 GKA 50
Glucokinase activator
6049 PF 04937319
Glucokinase partial activator
6345 PF 04991532
Potent hepatoselective glucokinase activator

Hexokinases catalyze the first essential step of glucose metabolism, the conversion of glucose into glucose-6-phosphate. This directly couples extramitochondrial glycolysis to intramitochondrial oxidative phosphorylation. There are two subtypes of mitochondrial hexokinases, HK1 and HK2, each of which has four isozymes designated hexokinase I, II, III and IV.

HK1 and HK2 are both localized to the outer mitochondrial membrane, with HK1 being found in nervous tissue and HK2 in insulin-responsive tissues such as skeletal muscle. Activation of mitochondrial hexokinases is regulated by Akt/PKB-mediated phosphorylation and they are subject to inhibiton by their end product, glucose-6-phosphate. In addition to glucose metabolism, mitochondrial hexokinases have been implicated in antiapoptotic and cell survival signaling.

Literature for Hexokinases

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Hexokinases Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
HK1 Human HK1 NM_000188 P19367
Mouse Hk1 NM_010438 P17710
Rat Hk1 NM_012734 P05708
HK2 Human HK2 NM_000189 P52789
Mouse Hk2 NM_013820 O08528
Rat Hk2 NM_012735 P27881