GKA 50

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Glucokinase activator
Chemical Name: 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino-3-pyridinecarboxylic acid
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for GKA 50

GKA 50 is a potent glucokinase activator (EC50 = 33 nM). Significantly reduces plasma glucose levels in diabetic rats; stimulates insulin release from mouse islets of Langerhans.

Compound Libraries for GKA 50

GKA 50 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GKA 50

M. Wt 464.51
Formula C26H28N2O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 851884-87-2
PubChem ID 11340230
Smiles O=C(NC3=NC=C(C(O)=O)C=C3)C1=CC(O[C@@H](C)COC)=CC(O[C@@H](C)CC2=CC=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GKA 50

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 46.45 100

Preparing Stock Solutions for GKA 50

The following data is based on the product molecular weight 464.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.76 mL 21.53 mL
5 mM 0.43 mL 2.15 mL 4.31 mL
10 mM 0.22 mL 1.08 mL 2.15 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for GKA 50

References are publications that support the biological activity of the product.

Coope et al (2006) Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats. Br.J.Pharmacol. 149 328 PMID: 16921397

Johnson et al (2007) Glucokinase activators: molecular tools for studying the physiology of Ins-Secr.g cells. Biochem.Soc.Trans. 35 1208 PMID: 17956314

If you know of a relevant reference for GKA 50, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Hexokinases Activators

Keywords: GKA 50, GKA 50 supplier, GKA50, glucokinases, hexokinase, IV, HK4, activators, activates, Hexokinases, 5133, Tocris Bioscience

Citations for GKA 50

Citations are publications that use Tocris products.

Currently there are no citations for GKA 50. Do you know of a great paper that uses GKA 50 from Tocris? Please let us know.

Reviews for GKA 50

There are currently no reviews for this product. Be the first to review GKA 50 and earn rewards!

Have you used GKA 50?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.