3-Bromopyruvate

Pricing Availability   Qty
Cat.No. 7512 - 3-Bromopyruvate | C3H3BrO3 | CAS No. 1113-59-3
Description: MCT1 inhibitor; also inhibits hexokinase II
Chemical Name: 3-Bromo-2-oxopropanoic acid
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for 3-Bromopyruvate

3-Bromopyruvate is a monocarboxylate transporter (MCT1) inhibitor (IC50 = 14.7 μM, 24.2 μM and 28.6 μM in SiHa, UM-UC-3, and HCT-116 human cancer cell lines, respectively). 3-Bromopyruvate shows antitumor activity in vitro and in vivo. 3-Bromopyruvate is also an inhibitor of hexokinase II, and decreases apoptosis in dopaminergic neurons in Parkinson's disease models in vitro and in vivo.

Technical Data for 3-Bromopyruvate

M. Wt 166.96
Formula C3H3BrO3
Storage Store at -20°C
CAS Number 1113-59-3
PubChem ID 70684
InChI Key PRRZDZJYSJLDBS-UHFFFAOYSA-N
Smiles O=C(O)C(=O)CBr

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 3-Bromopyruvate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 16.7 100

Preparing Stock Solutions for 3-Bromopyruvate

The following data is based on the product molecular weight 166.96. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.99 mL 29.95 mL 59.89 mL
5 mM 1.2 mL 5.99 mL 11.98 mL
10 mM 0.6 mL 2.99 mL 5.99 mL
50 mM 0.12 mL 0.6 mL 1.2 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for 3-Bromopyruvate

References for 3-Bromopyruvate

References are publications that support the biological activity of the product.

Vander Linden et al (2021) Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition. Cell Rep. 35 109202 PMID: 34077729

Li et al (2022) Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson's disease. Neurobiol. Dis. 163 105605 PMID: 34973450


If you know of a relevant reference for 3-Bromopyruvate, please let us know.

View Related Products by Product Action

View all Monocarboxylate Transporter Inhibitors

Keywords: 3-Bromopyruvate, 3-Bromopyruvate supplier, MCT1, monocarboxylate, transporters, 1, inhibitors, inhibits, anticancer, hexokinase, antitumor, antitumour, apoptosis, Parkinsons, disease, Monocarboxylate, Transporters, Hexokinases, 7512, Tocris Bioscience

Citations for 3-Bromopyruvate

Citations are publications that use Tocris products.

Currently there are no citations for 3-Bromopyruvate. Do you know of a great paper that uses 3-Bromopyruvate from Tocris? Please let us know.

Reviews for 3-Bromopyruvate

There are currently no reviews for this product. Be the first to review 3-Bromopyruvate and earn rewards!

Have you used 3-Bromopyruvate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis