Oxidative Phosphorylation

Oxidative phosphorylation is a combination of two simultaneous processes; the electron transport chain and chemiosmotic coupling. The electron transport chain (also known as the respiratory chain) comprises 4 complexes located in the inner mitochondrial membrane.

Products
Background
Literature

Inhibitors

Cat No Product Name / Activity
4979 Methylmalonate
Succinate dehydrogenase inhibitor
4849 3-Nitropropionic acid
Irreversible mitochondrial respiratory complex II inhibitor
3616 Rotenone
Inhibits complex I of the mitochondrial electron transport chain

Other

Cat No Product Name / Activity
5737 BAM 15
Mitochondrial protonophore uncoupler
0452 CCCP
Oxidative phosphorylation uncoupler
0453 FCCP
Oxidative phosphorylation uncoupler
0479 Malonoben
Oxidative phosphorylation uncoupler
5735 S3QEL 2
Suppressor of Complex III superoxide production

Oxidative phosphorylation is a combination of two simultaneous processes; the electron transport chain and chemiosmotic coupling. The electron transport chain (also known as the respiratory chain) comprises 4 complexes located in the inner mitochondrial membrane. NADH and FADH2, produced from glycolysis and the Krebs cycle, release electrons at certain points in the chain, which are passed from one electron acceptor to the next. Each time an electron is passed from one complex to the next, it loses energy.

Chemiosmotic coupling harnesses the energy from the electron transport chain and uses it to transport H+ across the inner mitochondrial membrane, establishing a concentration gradient. ATP synthase is found in the inner mitochondrial membrane and this enzyme uses the energy from H+ ion flux to synthesize ATP. Three ATP molecules can be made from each pair of electrons from NADH and two ATP molecules are made from a pair of electrons from FADH2.

Literature for Oxidative Phosphorylation

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New Product Guide (Spring/Summer 2017)

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  • 7-TM Receptors
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