Oxidative Phosphorylation

Oxidative phosphorylation is a combination of two simultaneous processes; the electron transport chain and chemiosmotic coupling. The electron transport chain (also known as the respiratory chain) comprises 4 complexes located in the inner mitochondrial membrane.

Products
Background

Oxidative Phosphorylation Inhibitors

Cat. No. Product Name / Activity
6980 BAY 87-2243
Mitochondrial complex I inhibitor
2864 Metformin hydrochloride
Mitochondrial complex I inhibitor; also activates LKB1/AMPK
4979 Methylmalonate
Succinate dehydrogenase inhibitor
3616 Rotenone
Inhibits complex I of the mitochondrial electron transport chain

Other

Cat. No. Product Name / Activity
5737 BAM 15
Mitochondrial protonophore uncoupler
0452 CCCP
Oxidative phosphorylation uncoupler
0453 FCCP
Oxidative phosphorylation uncoupler
4245 Meclizine dihydrochloride
Reduces mitochondrial respiration and increases glycolysis; neuroprotectant; also PXR agonist
6898 Mitochondrial fusion promoter M1
Mitochondrial fusion promoter

Oxidative phosphorylation is a combination of two simultaneous processes; the electron transport chain and chemiosmotic coupling. The electron transport chain (also known as the respiratory chain) comprises 4 complexes located in the inner mitochondrial membrane. NADH and FADH2, produced from glycolysis and the Krebs cycle, release electrons at certain points in the chain, which are passed from one electron acceptor to the next. Each time an electron is passed from one complex to the next, it loses energy.

Chemiosmotic coupling harnesses the energy from the electron transport chain and uses it to transport H+ across the inner mitochondrial membrane, establishing a concentration gradient. ATP synthase is found in the inner mitochondrial membrane and this enzyme uses the energy from H+ ion flux to synthesize ATP. Three ATP molecules can be made from each pair of electrons from NADH and two ATP molecules are made from a pair of electrons from FADH2.