Lonidamine

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Cat.No. 1646 - Lonidamine | C15H10Cl2N2O2 | CAS No. 50264-69-2
Description: Mitochondrial hexokinase inhibitor
Alternative Names: AF 1890
Chemical Name: 1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Anticancer and antispermatogenic agent in vitro and in vivo. Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl- channels in vitro.

Compound Libraries

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Technical Data

M. Wt 321.16
Formula C15H10Cl2N2O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 50264-69-2
PubChem ID 39562
InChI Key WDRYRZXSPDWGEB-UHFFFAOYSA-N
Smiles OC(=O)C1=NN(CC2=C(Cl)C=C(Cl)C=C2)C2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 1.61 5
DMSO 32.12 100

Preparing Stock Solutions

The following data is based on the product molecular weight 321.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.11 mL 15.57 mL 31.14 mL
5 mM 0.62 mL 3.11 mL 6.23 mL
10 mM 0.31 mL 1.56 mL 3.11 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

De Martino et al (1984) Effects of lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study. Oncology 41 15 PMID: 6717891

Gong et al (2002) Mechanism of lonidamine inhibition of the CFTR chloride channel. Br.J.Pharmacol. 137 928 PMID: 12411425

Lobl et al (1981) Effects of lonidamine (AF 1890) and its analogues on follicle-stimulating hormone, luteinizing hormone, testosterone and rat androgen binding protein concentrations in the rat and rhesus monkey. Chemotherapy 27 61 PMID: 6793318

Teiche (1994) Lonidamine: in vitro/in vivo correlations. Eur.J.Cancer 30A 1411 PMID: 7833093


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Keywords: Lonidamine, Lonidamine supplier, Mitochondrial, hexokinase, inhibitors, inhibits, CFTR, Cl-, chloride, channels, blockers, Carbohydrate, Metabolism, Kinases, AF1890, AF, 1890, Hexokinases, 1646, Tocris Bioscience

Citations for Lonidamine

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