Lonidamine
Biological Activity
Anticancer and antispermatogenic agent in vitro and in vivo. Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl- channels in vitro.
Compound Libraries
Lonidamine is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 321.16 |
| Formula | C15H10Cl2N2O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 50264-69-2 |
| PubChem ID | 39562 |
| InChI Key | WDRYRZXSPDWGEB-UHFFFAOYSA-N |
| Smiles | OC(=O)C1=NN(CC2=C(Cl)C=C(Cl)C=C2)C2=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.12 | 100 | |
| ethanol | 1.61 | 5 |
Preparing Stock Solutions
The following data is based on the product molecular weight 321.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.11 mL | 15.57 mL | 31.14 mL |
| 5 mM | 0.62 mL | 3.11 mL | 6.23 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.11 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
De Martino et al (1984) Effects of lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study. Oncology 41 15 PMID: 6717891
Gong et al (2002) Mechanism of lonidamine inhibition of the CFTR chloride channel. Br.J.Pharmacol. 137 928 PMID: 12411425
Lobl et al (1981) Effects of lonidamine (AF 1890) and its analogues on follicle-stimulating hormone, luteinizing hormone, testosterone and rat androgen binding protein concentrations in the rat and rhesus monkey. Chemotherapy 27 61 PMID: 6793318
Teiche (1994) Lonidamine: in vitro/in vivo correlations. Eur.J.Cancer 30A 1411 PMID: 7833093
If you know of a relevant reference for Lonidamine, please let us know.
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Keywords: Mitochondrial hexokinase inhibitors inhibits CFTR Cl- chloride channels blockers Carbohydrate Metabolism Kinases AF1890 AF 1890 Hexokinases
Citations for Lonidamine
Citations are publications that use Tocris products.
Currently there are no citations for Lonidamine. Do you know of a great paper that uses Lonidamine from Tocris? If so please let us know.
Literature in this Area
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