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Submit ReviewLonidamine
Description: Mitochondrial hexokinase inhibitor
Alternative Names: AF 1890
Chemical Name: 1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid
Purity: ≥98% (HPLC)
Biological Activity
Anticancer and antispermatogenic agent in vitro and in vivo. Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl- channels in vitro.
Compound Libraries
Lonidamine is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 321.16 |
| Formula | C15H10Cl2N2O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 50264-69-2 |
| PubChem ID | 39562 |
| InChI Key | WDRYRZXSPDWGEB-UHFFFAOYSA-N |
| Smiles | OC(=O)C1=NN(CC2=C(Cl)C=C(Cl)C=C2)C2=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 1.61 | 5 | |
| DMSO | 32.12 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 321.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.11 mL | 15.57 mL | 31.14 mL |
| 5 mM | 0.62 mL | 3.11 mL | 6.23 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.11 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
De Martino et al (1984) Effects of lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study. Oncology 41 15 PMID: 6717891
Gong et al (2002) Mechanism of lonidamine inhibition of the CFTR chloride channel. Br.J.Pharmacol. 137 928 PMID: 12411425
Lobl et al (1981) Effects of lonidamine (AF 1890) and its analogues on follicle-stimulating hormone, luteinizing hormone, testost. and rat androgen binding protein concentrations in the rat and rhesus monkey. Chemotherapy 27 61 PMID: 6793318
Teiche (1994) Lonidamine: in vitro/in vivo correlations. Eur.J.Cancer 30A 1411 PMID: 7833093
If you know of a relevant reference for Lonidamine, please let us know.
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Keywords: Lonidamine, Lonidamine supplier, Mitochondrial, hexokinase, inhibitors, inhibits, CFTR, Cl-, chloride, channels, blockers, Carbohydrate, Metabolism, Kinases, AF1890, AF, 1890, Hexokinases, 1646, Tocris Bioscience
1 Citation for Lonidamine
Citations are publications that use Tocris products. Selected citations for Lonidamine include:
Panina et al (2019) A mechanism for increased sensitivity of acute myeloid leukemia to mitotoxic drugs. Cell Death Dis 10 617 PMID: 31409768
Do you know of a great paper that uses Lonidamine from Tocris? Please let us know.
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