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Description: Mitochondrial hexokinase inhibitor
Alternative Names: AF 1890
Chemical Name: 1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for Lonidamine

Lonidamine is an anticancer and antispermatogenic agent in vitro and in vivo. Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl- channels in vitro.

Compound Libraries for Lonidamine

Lonidamine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for Lonidamine

M. Wt 321.16
Formula C15H10Cl2N2O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 50264-69-2
PubChem ID 39562
Smiles OC(=O)C1=NN(CC2=C(Cl)C=C(Cl)C=C2)C2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Lonidamine

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 1.61 5
DMSO 32.12 100

Preparing Stock Solutions for Lonidamine

The following data is based on the product molecular weight 321.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.11 mL 15.57 mL 31.14 mL
5 mM 0.62 mL 3.11 mL 6.23 mL
10 mM 0.31 mL 1.56 mL 3.11 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets for Lonidamine

Certificate of Analysis / Product Datasheet
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References for Lonidamine

References are publications that support the biological activity of the product.

De Martino et al (1984) Effects of lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study. Oncology 41 15 PMID: 6717891

Gong et al (2002) Mechanism of lonidamine inhibition of the CFTR chloride channel. Br.J.Pharmacol. 137 928 PMID: 12411425

Lobl et al (1981) Effects of lonidamine (AF 1890) and its analogues on follicle-stimulating hormone, luteinizing hormone, testost. and rat androgen binding protein concentrations in the rat and rhesus monkey. Chemotherapy 27 61 PMID: 6793318

Teiche (1994) Lonidamine: in vitro/in vivo correlations. Eur.J.Cancer 30A 1411 PMID: 7833093

If you know of a relevant reference for Lonidamine, please let us know.

View Related Products by Product Action

View all Hexokinases Inhibitors

Keywords: Lonidamine, Lonidamine supplier, Mitochondrial, hexokinase, inhibitors, inhibits, CFTR, Cl-, chloride, channels, blockers, Carbohydrate, Metabolism, Kinases, AF1890, AF, 1890, Hexokinases, 1646, Tocris Bioscience

1 Citation for Lonidamine

Citations are publications that use Tocris products. Selected citations for Lonidamine include:

Panina et al (2019) A mechanism for increased sensitivity of acute myeloid leukemia to mitotoxic drugs. Cell Death Dis 10 617 PMID: 31409768

Do you know of a great paper that uses Lonidamine from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.