Anticancer and antispermatogenic agent in vitro and in vivo. Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl- channels in vitro.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 321.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.11 mL||15.57 mL||31.14 mL|
|5 mM||0.62 mL||3.11 mL||6.23 mL|
|10 mM||0.31 mL||1.56 mL||3.11 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
References are publications that support the biological activity of the product.
De Martino et al (1984) Effects of lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study. Oncology 41 15 PMID: 6717891
Gong et al (2002) Mechanism of lonidamine inhibition of the CFTR chloride channel. Br.J.Pharmacol. 137 928 PMID: 12411425
Lobl et al (1981) Effects of lonidamine (AF 1890) and its analogues on follicle-stimulating hormone, luteinizing hormone, testosterone and rat androgen binding protein concentrations in the rat and rhesus monkey. Chemotherapy 27 61 PMID: 6793318
Teiche (1994) Lonidamine: in vitro/in vivo correlations. Eur.J.Cancer 30A 1411 PMID: 7833093
If you know of a relevant reference for Lonidamine, please let us know.
View Related Products by Product Action
Keywords: Lonidamine, Lonidamine supplier, Mitochondrial, hexokinase, inhibitors, inhibits, CFTR, Cl-, chloride, channels, blockers, Carbohydrate, Metabolism, Kinases, AF1890, AF, 1890, Hexokinases, 1646, Tocris Bioscience
Citations for Lonidamine
Citations are publications that use Tocris products.
Currently there are no citations for Lonidamine. Do you know of a great paper that uses Lonidamine from Tocris? Please let us know.
Reviews for Lonidamine
There are currently no reviews for this product. Be the first to review Lonidamine and earn rewards!
Have you used Lonidamine?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.