des-His1-[Glu9]-Glucagon (1-29) amide

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Cat.No. 2216 - des-His1-[Glu9)-Glucagon (1-29) amide | Ser-Gln-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-NH2 | CAS No. 110084-95-2
Description: Glucagon receptor antagonist
Datasheet
Citations (1)
Literature

Biological Activity

Glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitro. Blocks added glucagon-induced hyperglycemia in normal rabbits without affecting glycogenolysis in vivo. Also blocks endogenous glucagon-induced hyperglycemia in streptozocin diabetic rats.

Technical Data

M. Wt 3358.68
Formula C148H221N41O47S
Sequence SQGTFTSEYSKYLDSRRAQDFVQWLMNT

(Modifications: Thr-28 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 110084-95-2
PubChem ID 16133829
InChI Key RVXSASLSNHDASC-OSWDIKPLSA-N
Smiles [H]N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 3358.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.3 mL 1.49 mL 2.98 mL
5 mM 0.06 mL 0.3 mL 0.6 mL
10 mM 0.03 mL 0.15 mL 0.3 mL
50 mM 0.01 mL 0.03 mL 0.06 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Unson et al (1989) Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist. Peptides 10 1171 PMID: 2560175

Huypens et al (2000) Glucagon receptors on human islet cells contribute to glucose competence of insulin release. Diabetologia 43 1012 PMID: 10990079

Unson et al (1987) Synthetic peptide antagonists of glucagon. Proc.Natl.Acad.Sci.USA 84 4083 PMID:


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Keywords: des-His1-[Glu9)-Glucagon (1-29) amide, supplier, Glucagon, receptor, antagonists, antagonist, receptors, Glucagon, Receptor, Glucagon, Receptor, Tocris Bioscience

1 Citation for des-His1-[Glu9]-Glucagon (1-29) amide

Citations are publications that use Tocris products. Selected citations for des-His1-[Glu9]-Glucagon (1-29) amide include:

Weston et al (2015) Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2). Acta Pharmacol Sin 290 23009 PMID: 26198634


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