Galanin Receptors

Galanin is widely distributed in the central and peripheral nervous systems and the endocrine system. Three different galanin receptors (GAL1-3) have been identified. Disruption of galanin expression or galanin receptor signaling is seen in many multifactoral conditions.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
2699 AR-M 1896
GAL2 agonist
2696 Galanin (1-29) (rat, mouse)
Non-selective galanin receptor agonist
3008 Galanin (porcine)
Galanin receptor agonist
1450 Galanin (1-15) (porcine, rat)
Galanin receptor agonist peptide
1179 Galanin (1-30) (human)
Endogenous galanin receptor agonist
1451 Galanin (2-29) (rat)
Selective GAL2 peptide agonist
2085 Galnon
Non-selective galanin receptor agonist
3629 M 1145
Potent and selective GAL2 agonist
2697 M617
Selective GAL1 agonist
6090 Spexin
Potent GAL2/3 agonist; exhibits anxiolytic effects in vivo

Antagonists

Cat No Product Name / Activity
3425 M40
Potent, non-selective galanin receptor antagonist
2698 M871
Selective GAL2 antagonist

Galanin is widely distributed in the central and peripheral nervous systems and the endocrine system. Three different galanin receptors (GAL1-3) have been identified which are Gi/o-protein-coupled. They are highly expressed in hypothalamic nuclei and the brainstem. In addition, they are found in proliferating zones of the fetal and adult brain and in peripheral tissues including the pancreas, heart, skin and gastrointestinal tract.

Galanin receptors mediate a variety of physiological functions including inhibition of glucose-induced insulin secretion, stimulation of growth hormone release and modulation of gastrointestinal motility. These receptors also modulate neuronal functions including memory, nociception, spinal reflexes and feeding. Disruption of galanin expression or galanin receptor signaling is seen in many multifactoral conditions, suggesting a role in the development and/or pathology of certain diseases. These include Alzheimer's disease, epilepsy, diabetes, alcoholism, neuropathic pain and cancer.

External sources of pharmacological information for Galanin Receptors :

Literature for Galanin Receptors

GPCR

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Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

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  • Anterior Pituitary Regulation
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Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Galanin Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
GAL1 Human GALR1 NM_001480 P47211
Mouse Galr1 NM_008082 P56479
Rat Galr1 NM_012958 Q62805
GAL2 Human GALR2 NM_003857 O43603
Mouse Galr2 NM_010254 O88854
Rat Galr2 NM_019172 O08726
GAL3 Human GALR3 NM_003614 O60755
Mouse Galr3 NM_015738 O88853
Rat Galr3 NM_019173 O88626