M40

Pricing Availability Delivery Time Qty
Cat.No. 3425 - M40 | Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2 | CAS No. 143896-17-7
Description: Potent, non-selective galanin receptor antagonist
Alternative Names: Galanin (1-13)-Pro-Pro-(Ala-Leu-)2Ala amide
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) (Cat. No. 2696) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine (Cat. No. 0927) and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.

Technical Data

M. Wt 1981.33
Formula C94H145N23O24
Sequence GWTLNSAGYLLGPPPALALA

(Modifications: Ala-20 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 143896-17-7
PubChem ID 16133821
InChI Key OSGCBUDLRBUEGW-JZCUZNMGSA-N
Smiles [H]NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1981.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.5 mL 2.52 mL 5.05 mL
5 mM 0.1 mL 0.5 mL 1.01 mL
10 mM 0.05 mL 0.25 mL 0.5 mL
50 mM 0.01 mL 0.05 mL 0.1 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bartfai et al (1993) Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Proc.Natl.Acad.Sci.USA 90 11287 PMID:

Yuan et al (2002) Gastric effects of galanin and its interaction with leptin on brainstem neuronal activity. J.Pharm.Exp.Ther. 301 488 PMID:

Lu et al (2005) A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc.Natl.Acad.Sci.USA 102 874 PMID:


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Keywords: M40, supplier, Potent, non-selective, galanin, antagonists, GAL, GalR, Receptors, Galanin, (1-13)-Pro-Pro-(Ala-Leu-)2Ala, amide, Galanin, Receptors, Galanin, Receptors, Tocris Bioscience

Citations for M40

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