M40

Pricing Availability   Qty
Cat.No. 3425 - M40 | Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2 | CAS No. 143896-17-7
Description: Potent, non-selective galanin receptor antagonist
Alternative Names: Galanin (1-13)-Pro-Pro-(Ala-Leu-)2Ala amide
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) (Cat. No. 2696) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine (Cat. No. 0927) and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.

Technical Data

M. Wt 1981.33
Formula C94H145N23O24
Sequence GWTLNSAGYLLGPPPALALA

(Modifications: Ala-20 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 143896-17-7
PubChem ID 16133821
InChI Key OSGCBUDLRBUEGW-JZCUZNMGSA-N
Smiles [H]NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Bartfai et al (1993) Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Proc.Natl.Acad.Sci.USA 90 11287

Yuan et al (2002) Gastric effects of galanin and its interaction with leptin on brainstem neuronal activity. J.Pharm.Exp.Ther. 301 488

Lu et al (2005) A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc.Natl.Acad.Sci.USA 102 874


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View all Galanin Receptor Antagonists

Keywords: M40, M40 supplier, Potent, non-selective, galanin, antagonists, GAL, GalR, Receptors, Galanin, (1-13)-Pro-Pro-(Ala-Leu-)2Ala, amide, 3425, Tocris Bioscience

2 Citations for M40

Citations are publications that use Tocris products. Selected citations for M40 include:

Herring et al (2012) The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitability. J Mol Cell Cardiol 52 667 PMID: 22172449

Li (2017) Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats. Sci Rep 7 15317 PMID: 29127424


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Literature in this Area

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