Potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) (Cat. No. 2696) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine (Cat. No. 0927) and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.
(Modifications: Ala-20 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1981.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.5 mL||2.52 mL||5.05 mL|
|5 mM||0.1 mL||0.5 mL||1.01 mL|
|10 mM||0.05 mL||0.25 mL||0.5 mL|
|50 mM||0.01 mL||0.05 mL||0.1 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
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Keywords: M40, supplier, Potent, non-selective, galanin, antagonists, GAL, GalR, Receptors, Galanin, (1-13)-Pro-Pro-(Ala-Leu-)2Ala, amide, Galanin, Receptors, Galanin, Receptors, Tocris Bioscience
Citations for M40
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Literature in this Area
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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.