Potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) (Cat. No. 2696) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine (Cat. No. 0927) and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.
(Modifications: Ala-20 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1981.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.5 mL||2.52 mL||5.05 mL|
|5 mM||0.1 mL||0.5 mL||1.01 mL|
|10 mM||0.05 mL||0.25 mL||0.5 mL|
|50 mM||0.01 mL||0.05 mL||0.1 mL|
References are publications that support the products' biological activity.
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Keywords: M40, supplier, Potent, non-selective, galanin, antagonists, GAL, GalR, Receptors, Galanin, (1-13)-Pro-Pro-(Ala-Leu-)2Ala, amide, Galanin, Receptors, Galanin, Receptors, Tocris Bioscience
1 Citation for M40
Citations are publications that use Tocris products. Selected citations for M40 include:
Li (2017) Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats. Sci Rep 7 15317 PMID: 29127424
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