M871

Pricing Availability Delivery Time Qty
Cat.No. 2698 - M871 | Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Glu-His-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2 | CAS No. 908844-75-7
Description: Selective GAL2 antagonist
Alternative Names: Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide
Datasheet
Citations (4)
Literature

Biological Activity

Selective galanin GAL2 receptor antagonist (Ki values are 13.1 and 420 nM for GAL2 and GAL1 receptors respectively). Blocks the pro-nociceptive effect of GAL2 receptor agonists.

Technical Data

M. Wt 2287.64
Formula C108H163N27O28
Sequence WTLNSAGYLLGPEHPPPALALA

(Modifications: Ala-22 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 908844-75-7
PubChem ID 90477989
InChI Key BHKXASDHGWBINL-ZEHYZEGSSA-N
Smiles [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 30% acetonitrile

Preparing Stock Solutions

The following data is based on the product molecular weight 2287.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.44 mL 2.19 mL 4.37 mL
5 mM 0.09 mL 0.44 mL 0.87 mL
10 mM 0.04 mL 0.22 mL 0.44 mL
50 mM 0.01 mL 0.04 mL 0.09 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Jimenez-Andrade et al (2006) Activation of peripheral galanin receptors: differential effects on nociception. Pharmacol.Biochem.Behav. 85 273 PMID: 16996122

Sollenburg et al (2006) M871 - a novel peptide antagonist selectively recognizing the galanin receptor type 2. Int.J.Pept.Res.Ther. 12 115 PMID:


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Keywords: Selective GAL2 GalR2 antagonists Receptors Galanin Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide Galanin Receptors

4 Citations for M871

Citations are publications that use Tocris products. Selected citations for M871 include:

Zhang (2017) Involvement of galanin and galanin receptor 2 in nociceptive modulation in anterior cingulatecortex of normal rats and rats with mononeuropathy Sci Rep 7 45930 PMID: 28378856

Scanlon et al (2015) Galanin modulates the neural niche to favour perineural invasion in head and neck cancer. Int J Neuropsychopharmacol 6 6885 PMID: 25917569

Millón et al (2015) A role for galanin N-terminal fragment (1-15) in anxiety- and depression-related behaviors in rats. Immun Inflamm Dis 18 PMID: 25522404

Millòn et al (2014) A role for galanin N-terminal fragment (1-15) in anxiety- and depression-related behaviors in rats. Int.J.Neuropsychopharmacol. 18 PMID: 25522404


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