Galanin (1-29) (rat, mouse)

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Cat.No. 2696 - Galanin (1-29) (rat, mouse) | Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-Asp-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-His-Gly-Leu-Thr-NH2 | CAS No. 114547-31-8
Description: Non-selective galanin receptor agonist
Datasheet
Citations (4)
Reviews
Literature

Biological Activity

Non-selective galanin receptor agonist (Ki values are 0.98, 1.48 and 1.47 nM for GAL1, GAL2 and GAL3 respectively). Anticonvulsant; prevents the occurrence of full kindled seizures in rats.

Technical Data

M. Wt 3164.48
Formula C141H211N43O41
Sequence GWTLNSAGYLLGPHAIDNHRSFSDKHGLT

(Modifications: Thr-29 = C-terminal amide)

Storage Store at -20°C
CAS Number 114547-31-8
PubChem ID 16201477
InChI Key JHQDYHHNJBOXKP-UPNHMZDKSA-N
Smiles [H]NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Wang et al (1997) Cloning and expression characterization of a novel galanin receptor. J.Biol.Chem. 272 51 PMID: 8995226

Mazarati et al (2006) Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: the effects of subtype-selective agonists and the role of G-protein-mediated signaling. J.Pharmacol.Exp.Ther. 318 700 PMID: 16699066

Branchek et al (2000) Galanin receptor subtypes. TiPS. 21 109


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Keywords: Galanin (1-29) (rat, mouse), Galanin (1-29) (rat, mouse) supplier, Non-Selective, galanin, receptors, agonists, GAL, GalR, Galanin, Receptors, 2696, Tocris Bioscience

4 Citations for Galanin (1-29) (rat, mouse)

Citations are publications that use Tocris products. Selected citations for Galanin (1-29) (rat, mouse) include:

Einstein et al (2013) Galanin-induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and morphine conditioned place preference require both galanin receptor 1 and galanin receptor 2. Eur J Neurosci 37 1541 PMID: 23387435

Funck (2018) Dorsal hippocampal galanin modulates anxiety-like behaviours in rats. Brain Res 1687 74 PMID: 29499176

Zhang (2017) Involvement of galanin and galanin receptor 2 in nociceptive modulation in anterior cingulatecortex of normal rats and rats with mononeuropathy. Sci Rep 7 45930 PMID: 28378856

Li (2017) Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats. Sci Rep 7 15317 PMID: 29127424


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