M617

Pricing Availability   Qty
Cat.No. 2697 - M617 | Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-NH2 | CAS No. 860790-38-1
Description: Selective GAL1 agonist
Alternative Names: Galanin(1-13)-Gln14-bradykinin(2-9)amide
Datasheet
Citations (1)
Reviews
Literature (3)

Biological Activity

Selective galanin GAL1 receptor agonist (Ki values are 0.23 and 5.71 nM for GAL1 and GAL2 receptors respectively). Enhances food consumption in rats following i.c.v. administration and reduces CAP-induced inflammatory pain.

Technical Data

M. Wt 2361.68
Formula C112H161N29O28
Sequence GWTLNSAGYLLGPQPPGFSPFR

(Modifications: Arg-22 = C-terminal amide)

Storage Store at -20°C
CAS Number 860790-38-1
PubChem ID 16158157
InChI Key PAYBRARNTYCYOT-OTTBQUPZSA-N
Smiles [H]NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Mazarati et al (2006) Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: the effects of subtype-selective agonists and the role of G-protein-mediated signaling. J.Pharmacol.Exp.Ther. 318 700 PMID: 16699066

Jimenez-Andrade et al (2006) Activation of peripheral galanin receptors: differential effects on nociception. Pharmacol.Biochem.Behav. 85 273 PMID: 16996122

Lundstrom et al (2005) A galanin receptor subtype 1 specific agonist. Int.J.Pept.Res.Ther. 11 17


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Keywords: M617, M617 supplier, Selective, GAL1, GalR1, agonists, Receptors, Galanin, Galanin(1-13)-Gln14-bradykinin(2-9)amide, 2697, Tocris Bioscience

1 Citation for M617

Citations are publications that use Tocris products. Selected citations for M617 include:

Li (2017) Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats. Sci Rep 7 15317 PMID: 29127424


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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