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Description: Potent GAL2/3 agonist; exhibits anxiolytic effects in vivo
Alternative Names: NPQ,Neuropeptide Q
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity for Spexin

Spexin is a potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet-induced obese mice and rats. Attenuates LH secretion in goldfish. Exhibits anxiolytic effects in vivo.

Technical Data for Spexin

M. Wt 1619.9
Formula C74H114N20O19S

(Modifications: Gln-14 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1370290-58-6
PubChem ID 122705996
Smiles [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Spexin

Solubility Soluble to 1 mg/ml in water

Product Datasheets for Spexin

Certificate of Analysis / Product Datasheet
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References for Spexin

References are publications that support the biological activity of the product.

Walewski et al (2014) Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity Obesity (Silver Spring) 22 1643 PMID: 24550067

Reyes-Alcaraz et al (2016) Development of spexin-based human galanin receptor type II-specific agonists with increased stability in serum and anxiolytic effect in mice. Sci.Rep. 6 21453 PMID: 26907960

Kim et al (2014) Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. Endocrinology 155 1864 PMID: 24517231

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Keywords: Spexin, Spexin supplier, Potent, galanin, receptors, 2, 3, agonists, agonism, GAL, endogenous, satiety, inducing, peptides, anxiolytic, anxiety, diabetes, obesity, NPQ, Neuropeptide, Q, Galanin, Receptors, 6090, Tocris Bioscience

Citations for Spexin

Citations are publications that use Tocris products.

Currently there are no citations for Spexin. Do you know of a great paper that uses Spexin from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.