δ Opioid Receptors

The δ opioid receptor (also known as OP1, DOP, DOR) is a member of the opioid family of G-protein-coupled receptors that also includes μ, κ and NOP receptors. In the CNS, δ opioid receptors are primarily distributed in the olfactory bulb, nucleus accumbens and neocortex.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
4335 AR-M 1000390 hydrochloride
Low-internalizing δ agonist
1663 BW 373U86
Potent, selective non-peptide δ agonist
3790 DADLE
Prototypical δ agonist
4591 Deltorphin I
Potent δ agonist
1180 [D-Ala2]-Deltorphin II
Selective δ agonist peptide
1431 DPDPE
Selective δ agonist
1480 FIT
Irreversible δ agonist
2962 6'-GNTI dihydrochloride
Selective κ/δ opioid heterodimer receptor agonist
0921 SB 205607 dihydrobromide
Selective, high affinity non-peptide δ1 agonist
1529 SNC 162
Potent, selective non-peptide δ agonist
0764 SNC 80
Highly selective non-peptide δ agonist

Antagonists

Cat No Product Name / Activity
0754 N-Benzylnaltrindole hydrochloride
Selective non-peptide δ2 antagonist
0899 BNTX maleate
Standard δ1 selective antagonist
0827 ICI 154,129
δ selective peptide antagonist
0820 ICI 174,864
δ selective peptide antagonist
0892 Naltriben mesylate
Standard δ2 selective antagonist
0740 Naltrindole hydrochloride
Selective non-peptide δ antagonist
1410 SDM25N hydrochloride
Potent, selective non-peptide δ antagonist; also inhibits dengue virus replication

Modulators

Cat No Product Name / Activity
5983 BMS 986187
Potent δ-opioid receptor positive allosteric modulator

The δ opioid receptor (also known as OP1, DOP, DOR) is a member of the opioid family of G-protein-coupled receptors that also includes μ, κ and NOP receptors. In the CNS, δ opioid receptors are primarily distributed in the olfactory bulb, nucleus accumbens, caudate putamen and neocortex, with low-moderate levels present in the thalamus, hypothalamus and brainstem.

δ opioid receptors play a role in analgesia, motor integration, gastrointestinal motility, olfaction, respiration, cognitive function and mood driven behavior. The enkephalins are generally considered to be the preferred endogenous ligands. The human gene encoding the δ opioid receptor has been localized to chromosome 1 (1p36.1-p34.3).

External sources of pharmacological information for δ Opioid Receptors :

Literature for δ Opioid Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Addiction

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

δ Opioid Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human OPRD1 NM_000911 P41143
Mouse Oprd1 NM_013622 P32300
Rat Oprd1 NM_012617 P33533