You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
A highly selective and potent non-peptide δ-opioid agonist, 2000-fold selective over μ-opioid receptors.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|1eq. HCl||44.96||100 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 449.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.22 mL||11.12 mL||22.24 mL|
|5 mM||0.44 mL||2.22 mL||4.45 mL|
|10 mM||0.22 mL||1.11 mL||2.22 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References are publications that support the biological activity of the product.
Bilsky et al (1995) SNC 80, a selective, nonpeptidic and systemically active opioid δ agonist. J.Pharmacol.Exp.Ther. 273 359 PMID: 7714789
Calderon et al (1994) Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC80): a highly selective nonpeptid J.Med.Chem. 37 2125 PMID: 8035418
Knapp et al (1996) Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors. J.Pharmacol.Exp.Ther. 277 1284 PMID: 8667189
If you know of a relevant reference for SNC 80, please let us know.
View Related Products by Product Action
Keywords: SNC 80, SNC 80 supplier, selective, non-peptide, δ-opioid, delta-opioid, agonists, DOP, Receptors, OP1, SNC80, Delta, Opioid, 0764, Tocris Bioscience
18 Citations for SNC 80
Citations are publications that use Tocris products. Selected citations for SNC 80 include:
Robins et al (2018) Critical Role for Gi/o-Protein Activity in the Dorsal Striatum in the Reduction of Voluntary Alcohol Intake in C57Bl/6 Mice. Front Psychiatry 9 112 PMID: 29686629
Burbassi et al (2010) Alterations of CXCR4 function in μ-opioid receptor-deficient glia. Eur J Neurosci 32 1278 PMID: 20880358
Milan-Lobo et al (2013) Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism. PLoS One 8 e58362 PMID: 23554887
Butelman et al (2010) The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects. Psychopharmacology (Berl) 210 253 PMID: 20084367
Scherrer et al (2006) Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo. Proc Natl Acad Sci U S A 103 9691 PMID: 16766653
Neumann et al (2015) The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3. J Invest Dermatol 135 471 PMID: 25178105
Pacheco et al (2009) Central antinociception induced by mu-opioid receptor agonist morphine, but not delta- or kappa-, is mediated by cannabinoid CB1 receptor. Br J Pharmacol 158 225 PMID: 19594755
Sluka et al (2002) Chronic muscle pain induced by repeated acid Injection is reversed by spinally administered mu- and delta-, but not kappa-, opioid receptor agonists. J Pharmacol Exp Ther 302 1146 PMID: 12183674
Gomes et al (2000) Heterodimerization of μ and δ opioid receptors: A role in opiate synergy. Br J Pharmacol 20 RC110 PMID: 11069979
Pradhan et al (2014) δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice. Br J Pharmacol 171 2375 PMID: 24467301
Wang et al (2018) Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits. Neuron 98 90 PMID: 29576387
Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086 PMID: 18703511
Pacheco et al (2008) The mu-opioid receptor agonist morphine, but not agonists at delta- or kappa-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors. Br J Pharmacol 154 1143 PMID: 18469844
Ye (2017) Alterations in opioid inhibition cause widespread nociception but do not affect anxiety-like behavior in oral cancer mice. Neuroscience 363 50 PMID: 28673713
Ong et al (2015) Prolonged mor. treatment alters δ opioid receptor post-internalization trafficking. Front Endocrinol (Lausanne) 172 615 PMID: 24819092
Levoye et al (2015) A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate. Brain Struct Funct 6 167 PMID: 26617570
Erbs et al (2015) A μ-δ opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks. J Neurosci 220 677 PMID: 24623156
Schuster et al (2015) Ligand requirements for involvement of PKCη in synergistic analgesic interactions between spinal μ and δ opioid receptors. Transl Oncol 172 642 PMID: 24827408
Do you know of a great paper that uses SNC 80 from Tocris? Please let us know.
Reviews for SNC 80
There are currently no reviews for this product. Be the first to review SNC 80 and earn rewards!
Have you used SNC 80?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.