SNC 80

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Cat.No. 0764 - SNC 80 | C28H39N3O2 | CAS No. 156727-74-1
Description: Highly selective non-peptide δ agonist
Chemical Name: (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations (9)
Literature

Biological Activity

A highly selective and potent non-peptide δ-opioid agonist, 2000-fold selective over μ-opioid receptors.

Compound Libraries

SNC 80 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 449.64
Formula C28H39N3O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 156727-74-1
PubChem ID 123924
InChI Key KQWVAUSXZDRQPZ-UMTXDNHDSA-N
Smiles [H][C@@](N1C[C@@H](C)N(CC=C)C[C@@H]1C)(C1=CC=C(C=C1)C(=O)N(CC)CC)C1=CC=CC(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 44.96 100mM with gentle warming
DMSO 8.99 20

Preparing Stock Solutions

The following data is based on the product molecular weight 449.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.12 mL 22.24 mL
5 mM 0.44 mL 2.22 mL 4.45 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bilsky et al (1995) SNC 80, a selective, nonpeptidic and systemically active opioid δ agonist. J.Pharmacol.Exp.Ther. 273 359 PMID: 7714789

Calderon et al (1994) Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC80): a highly selective nonpeptid J.Med.Chem. 37 2125 PMID: 8035418

Knapp et al (1996) Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors. J.Pharmacol.Exp.Ther. 277 1284 PMID: 8667189


If you know of a relevant reference for SNC 80, please let us know.

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Keywords: SNC 80, supplier, selective, non-peptide, δ-opioid, delta-opioid, agonists, DOP, Receptors, OP1, SNC80, Delta, Opioid, Receptors, Tocris Bioscience

9 Citations for SNC 80

Citations are publications that use Tocris products. Selected citations for SNC 80 include:

Burbassi et al (2010) Alterations of CXCR4 function in μ-opioid receptor-deficient glia. Eur J Neurosci 32 1278 PMID: 20880358

Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086 PMID: 18703511

Scherrer et al (2006) Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo. Proc Natl Acad Sci U S A 103 9691 PMID: 16766653

Gomes et al (2000) Heterodimerization of μ and δ opioid receptors: A role in opiate synergy. Br J Pharmacol 20 RC110 PMID: 11069979

Ong et al (2015) Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking. Front Endocrinol (Lausanne) 172 615 PMID: 24819092

Levoye et al (2015) A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate. Brain Struct Funct 6 167 PMID: 26617570

Erbs et al (2015) A μ-δ opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks. J Neurosci 220 677 PMID: 24623156

Schuster et al (2015) Ligand requirements for involvement of PKCη in synergistic analgesic interactions between spinal μ and δ opioid receptors. Transl Oncol 172 642 PMID: 24827408

Pradhan et al (2014) δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice. Br J Pharmacol 171 2375 PMID: 24467301


Do you know of a great paper that uses SNC 80 from Tocris? If so please let us know.

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