The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of G-protein-coupled receptors that also includes κ, δ and μ receptors. The human gene encoding the NOP receptor has been localized to chromosome 20 (20q13.33).
Agonists |
|
|---|---|
| Cat No | Product Name / Activity |
| 3763 | MCOPPB trihydrochloride |
| Potent NOP receptor agonist | |
| 1780 | NNC 63-0532 |
| Potent non-peptide NOP agonist; brain penetrant | |
| 0910 | Nociceptin |
| Endogenous NOP agonist | |
| 1358 | Nociceptin (1-13)NH2 |
| Potent ORL1 agonist | |
| 1590 | [Arg14,Lys15]Nociceptin |
| Highly potent and selective NOP agonist | |
| 1566 | [(pF)Phe4]Nociceptin(1-13)NH2 |
| Potent, selective nociceptin receptor agonist | |
| 1092 | [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 |
| Selective nociceptin receptor agonist | |
| 3932 | Orphanin FQ (1-11) |
| Potent NOP agonist; displays analgesic properties | |
| 1387 | Ac-RYYRWK-NH2 |
| Potent, selective NOP partial agonist peptide | |
| 3240 | SCH 221510 |
| Potent and selective NOP agonist | |
Antagonists |
|
| Cat No | Product Name / Activity |
| 3661 | BAN ORL 24 |
| Potent and selective NOP antagonist | |
| 2598 | (±)-J 113397 |
| Potent and selective NOP antagonist | |
| 2481 | JTC 801 |
| Selective NOP antagonist | |
| 1308 | [Nphe1]Nociceptin(1-13)NH2 |
| Selective, competitive nociceptin antagonist | |
| 1118 | Nocistatin (bovine) |
| Opposes action of nociceptin | |
| 1198 | Nocistatin (human) |
| Human putative counterpart of nocistatin | |
| 3573 | SB 612111 hydrochloride |
| Selective NOP receptor antagonist | |
| 2508 | Trap 101 |
| Potent and selective NOP antagonist; active in vivo | |
| 1552 | UFP-101 |
| Potent, selective silent antagonist for NOP | |
Ligands |
|
| Cat No | Product Name / Activity |
| 1239 | Ac-RYYRIK-NH2 |
| High affinity NOP ligand | |
Other |
|
| Cat No | Product Name / Activity |
| 1266 | Nociceptin (1-7) |
| Bioactive metabolite of nociceptin | |
| 1119 | NocII |
| Orphan neuropeptide | |
The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of G-protein-coupled receptors that also includes κ, δ and μ receptors. NOP receptor mRNA is found in high levels in the cortex, anterior olfactory nucleus, lateral septum, hypothalamus, hippocampus, amygdala, central grey, pontine nuclei, interpeduncular nucleus, substantia nigra, raphe complex, locus coeruleus and spinal cord.
The pattern of NOP receptor distribution suggests the involvement of the NOP receptor in motor and balance control, reinforcement and reward, nociception, the stress response, sexual behavior, aggression and autonomic control of physiological processes. The human gene encoding the NOP receptor has been localized to chromosome 20 (20q13.33).
External sources of pharmacological information for NOP Receptors :