NOP Receptors
The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of G-protein-coupled receptors that also includes κ, δ and μ receptors. The human gene encoding the NOP receptor has been localized to chromosome 20 (20q13.33).
NOP Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 2808 | Buprenorphine hydrochloride |
| NOP agonist; also displays mixed action δ, κ and μ receptors | |
| 3763 | MCOPPB trihydrochloride |
| Potent NOP receptor agonist | |
| 1780 | NNC 63-0532 |
| Potent non-peptide NOP agonist; brain penetrant | |
| 0910 | Nociceptin |
| Endogenous NOP agonist | |
| 1092 | [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 |
| Selective nociceptin receptor agonist | |
| 1387 | Ac-RYYRWK-NH2 |
| Potent, selective NOP partial agonist peptide | |
| 3240 | SCH 221510 |
| Potent and selective NOP agonist | |
NOP Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 2598 | (±)-J 113397 |
| Potent and selective NOP antagonist | |
| 2481 | JTC 801 |
| Selective NOP antagonist | |
| 1198 | Nocistatin (human) |
| Human putative counterpart of nocistatin | |
| 3573 | SB 612111 hydrochloride |
| Selective NOP antagonist | |
| 1552 | UFP-101 |
| Potent, selective silent antagonist for NOP | |
Ligands |
|
| Cat. No. | Product Name / Activity |
| 1239 | Ac-RYYRIK-NH2 |
| High affinity NOP ligand | |
Other |
|
| Cat. No. | Product Name / Activity |
| 1119 | NocII |
| Orphan neuropeptide | |
The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of G-protein-coupled receptors that also includes κ, δ and μ receptors. NOP receptor mRNA is found in high levels in the cortex, anterior olfactory nucleus, lateral septum, hypothalamus, hippocampus, amygdala, central grey, pontine nuclei, interpeduncular nucleus, substantia nigra, raphe complex, locus coeruleus and spinal cord.
The pattern of NOP receptor distribution suggests the involvement of the NOP receptor in motor and balance control, reinforcement and reward, nociception, the stress response, sexual behavior, aggression and autonomic control of physiological processes. The human gene encoding the NOP receptor has been localized to chromosome 20 (20q13.33).
External sources of pharmacological information for NOP Receptors :
Literature for NOP Receptors
Tocris offers the following scientific literature for NOP Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
Pain Research Product Guide
A collection of over 280 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Cardiovascular Poster
Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.
Pain Poster
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Our Pain guide highlights over 280 products for Pain research.
Request copyRequest PDF
Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis.
Request copyRequest PDFWritten by J.J. Maguire and A.P. Davenport
Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity.
Request copyDownload PDFWritten by Grant D. Nicol and Michael R. Vasko
Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization.
Request copyDownload PDF