NOP Receptors
The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of G-protein-coupled receptors that also includes κ, δ and μ receptors. The human gene encoding the NOP receptor has been localized to chromosome 20 (20q13.33).
NOP Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 2808 | Buprenorphine hydrochloride |
| NOP agonist; also displays mixed action δ, κ and μ receptors | |
| 1780 | NNC 63-0532 |
| Potent non-peptide NOP agonist; brain penetrant | |
| 0910 | Nociceptin |
| Endogenous NOP agonist | |
| 1092 | [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 |
| Selective nociceptin receptor agonist | |
| 1387 | Ac-RYYRWK-NH2 |
| Potent, selective NOP partial agonist peptide | |
| 3240 | SCH 221510 |
| Potent and selective NOP agonist | |
NOP Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 2598 | (±)-J 113397 |
| Potent and selective NOP antagonist | |
| 2481 | JTC 801 |
| Selective NOP antagonist | |
| 1198 | Nocistatin (human) |
| Human putative counterpart of nocistatin | |
| 3573 | SB 612111 hydrochloride |
| Selective NOP antagonist | |
| 1552 | UFP-101 |
| Potent, selective silent antagonist for NOP | |
Ligands |
|
| Cat. No. | Product Name / Activity |
| 1239 | Ac-RYYRIK-NH2 |
| High affinity NOP ligand | |
Other |
|
| Cat. No. | Product Name / Activity |
| 1119 | NocII |
| Orphan neuropeptide | |
The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of G-protein-coupled receptors that also includes κ, δ and μ receptors. NOP receptor mRNA is found in high levels in the cortex, anterior olfactory nucleus, lateral septum, hypothalamus, hippocampus, amygdala, central grey, pontine nuclei, interpeduncular nucleus, substantia nigra, raphe complex, locus coeruleus and spinal cord.
The pattern of NOP receptor distribution suggests the involvement of the NOP receptor in motor and balance control, reinforcement and reward, nociception, the stress response, sexual behavior, aggression and autonomic control of physiological processes. The human gene encoding the NOP receptor has been localized to chromosome 20 (20q13.33).
External sources of pharmacological information for NOP Receptors :
Literature for NOP Receptors
Tocris offers the following scientific literature for NOP Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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Our Pain guide highlights over 280 products for Pain research.
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Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis.
Request copyRequest PDFWritten by J.J. Maguire and A.P. Davenport
Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity.
Request copyDownload PDFWritten by Grant D. Nicol and Michael R. Vasko
Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization.
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