NOP Receptors

The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of G-protein-coupled receptors that also includes κ, δ and μ receptors. The human gene encoding the NOP receptor has been localized to chromosome 20 (20q13.33).

Products
Background
Gene Data

Agonists

Cat No Product Name / Activity
3763 MCOPPB trihydrochloride
Potent NOP receptor agonist
1780 NNC 63-0532
Potent non-peptide NOP agonist; brain penetrant
0910 Nociceptin
Endogenous NOP agonist
1358 Nociceptin (1-13)NH2
Potent ORL1 agonist
1590 [Arg14,Lys15]Nociceptin
Highly potent and selective NOP agonist
1566 [(pF)Phe4]Nociceptin(1-13)NH2
Potent, selective nociceptin receptor agonist
1092 [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2
Selective nociceptin receptor agonist
3932 Orphanin FQ (1-11)
Potent NOP agonist; displays analgesic properties
1387 Ac-RYYRWK-NH2
Potent, selective NOP partial agonist peptide
3240 SCH 221510
Potent and selective NOP agonist

Antagonists

Cat No Product Name / Activity
3661 BAN ORL 24
Potent and selective NOP antagonist
2598 (±)-J 113397
Potent and selective NOP antagonist
2481 JTC 801
Selective NOP antagonist
1308 [Nphe1]Nociceptin(1-13)NH2
Selective, competitive nociceptin antagonist
1118 Nocistatin (bovine)
Opposes action of nociceptin
1198 Nocistatin (human)
Human putative counterpart of nocistatin
3573 SB 612111 hydrochloride
Selective NOP receptor antagonist
2508 Trap 101
Potent and selective NOP antagonist; active in vivo
1552 UFP-101
Potent, selective silent antagonist for NOP

Ligands

Cat No Product Name / Activity
1239 Ac-RYYRIK-NH2
High affinity NOP ligand

Other

Cat No Product Name / Activity
1266 Nociceptin (1-7)
Bioactive metabolite of nociceptin
1119 NocII
Orphan neuropeptide

The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of G-protein-coupled receptors that also includes κ, δ and μ receptors. NOP receptor mRNA is found in high levels in the cortex, anterior olfactory nucleus, lateral septum, hypothalamus, hippocampus, amygdala, central grey, pontine nuclei, interpeduncular nucleus, substantia nigra, raphe complex, locus coeruleus and spinal cord.

The pattern of NOP receptor distribution suggests the involvement of the NOP receptor in motor and balance control, reinforcement and reward, nociception, the stress response, sexual behavior, aggression and autonomic control of physiological processes. The human gene encoding the NOP receptor has been localized to chromosome 20 (20q13.33).

External sources of pharmacological information for NOP Receptors :

NOP Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human OPRL1 NM_000913 P41146
Mouse Oprl1 NM_011012 P35377
Rat Oprl1 NM_031569 P35370