NOP Receptors
The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of G-protein-coupled receptors that also includes κ, δ and μ receptors. The human gene encoding the NOP receptor has been localized to chromosome 20 (20q13.33).
Agonists |
|
|---|---|
| Cat No | Product Name / Activity |
| 3763 | MCOPPB trihydrochloride |
| Potent NOP receptor agonist | |
| 1780 | NNC 63-0532 |
| Potent non-peptide NOP agonist; brain penetrant | |
| 0910 | Nociceptin |
| Endogenous NOP agonist | |
| 1358 | Nociceptin (1-13)NH2 |
| Potent ORL1 agonist | |
| 1590 | [Arg14,Lys15]Nociceptin |
| Highly potent and selective NOP agonist | |
| 1566 | [(pF)Phe4]Nociceptin(1-13)NH2 |
| Potent, selective nociceptin receptor agonist | |
| 1092 | [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 |
| Selective nociceptin receptor agonist | |
| 3932 | Orphanin FQ (1-11) |
| Potent NOP agonist; displays analgesic properties | |
| 1387 | Ac-RYYRWK-NH2 |
| Potent, selective NOP partial agonist peptide | |
| 3240 | SCH 221510 |
| Potent and selective NOP agonist | |
Antagonists |
|
| Cat No | Product Name / Activity |
| 3661 | BAN ORL 24 |
| Potent and selective NOP antagonist | |
| 2598 | (±)-J 113397 |
| Potent and selective NOP antagonist | |
| 2481 | JTC 801 |
| Selective NOP antagonist | |
| 1308 | [Nphe1]Nociceptin(1-13)NH2 |
| Selective, competitive nociceptin antagonist | |
| 1118 | Nocistatin (bovine) |
| Opposes action of nociceptin | |
| 1198 | Nocistatin (human) |
| Human putative counterpart of nocistatin | |
| 3573 | SB 612111 hydrochloride |
| Selective NOP receptor antagonist | |
| 2508 | Trap 101 |
| Potent and selective NOP antagonist; active in vivo | |
| 1552 | UFP-101 |
| Potent, selective silent antagonist for NOP | |
Ligands |
|
| Cat No | Product Name / Activity |
| 1239 | Ac-RYYRIK-NH2 |
| High affinity NOP ligand | |
Other |
|
| Cat No | Product Name / Activity |
| 1266 | Nociceptin (1-7) |
| Bioactive metabolite of nociceptin | |
| 1119 | NocII |
| Orphan neuropeptide | |
The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of G-protein-coupled receptors that also includes κ, δ and μ receptors. NOP receptor mRNA is found in high levels in the cortex, anterior olfactory nucleus, lateral septum, hypothalamus, hippocampus, amygdala, central grey, pontine nuclei, interpeduncular nucleus, substantia nigra, raphe complex, locus coeruleus and spinal cord.
The pattern of NOP receptor distribution suggests the involvement of the NOP receptor in motor and balance control, reinforcement and reward, nociception, the stress response, sexual behavior, aggression and autonomic control of physiological processes. The human gene encoding the NOP receptor has been localized to chromosome 20 (20q13.33).
External sources of pharmacological information for NOP Receptors :
Literature for NOP Receptors
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Secretin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
Pain Research Product Guide
A collection of over 250 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Cardiovascular Poster
Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.
Pain Poster
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Our Pain guide highlights over 280 products for Pain research.
Request copyDownload PDF
Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis.
Download PDF
Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity.
Request copyDownload PDF
Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization.
Request copyDownload PDF