SB 205607 dihydrobromide

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Description: Selective, high affinity non-peptide δ1 agonist
Alternative Names: TAN 67
Chemical Name: (R*,S*)-(±)-2-Methyl-4aa-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12aa-octahydroquinolino[2,3,3-g]isoquinoline dihydrobromide
Purity: ≥97% (HPLC)
Citations (2)
Literature (2)

Biological Activity for SB 205607 dihydrobromide

The first described non-peptide δ1 opioid receptor agonist with very high affinity and selectivity for the δ1 subtype (Ki values are 1.12, 2320 and 1790 nM at δ1, μ and κ receptors respectively).

Licensing Information

Sold under license

Compound Libraries for SB 205607 dihydrobromide

SB 205607 dihydrobromide is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SB 205607 dihydrobromide

M. Wt 506.28
Formula C23H24N2O.2HBr
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 1217628-73-3
PubChem ID 56972161
Smiles [H][C@@](C1)2[C@](CC(N=C(C=CC=C4)C4=C3)=C3C2)([C@]5=CC=CC(O)=C5)CCN1C.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SB 205607 dihydrobromide

Solvent Max Conc. mg/mL Max Conc. mM
water 50.63 100
DMSO 50.63 100

Preparing Stock Solutions for SB 205607 dihydrobromide

The following data is based on the product molecular weight 506.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.88 mL 19.75 mL
5 mM 0.4 mL 1.98 mL 3.95 mL
10 mM 0.2 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets for SB 205607 dihydrobromide

Certificate of Analysis / Product Datasheet
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References for SB 205607 dihydrobromide

References are publications that support the biological activity of the product.

Kamei et al (1995) Antinociceptive effects of the selective non-peptidic δ-opioid receptor agonist TAN-67 in diabetic mice. Eur.J.Pharmacol. 276 131 PMID: 7781682

Knap et al (1995) Properties of TAN-67, a non-peptidic β-opioid receptor agonist, at cloned human δ- and μ-opioid receptors. Eur.J.Pharmacol. 291 129 PMID: 8566162

Nagase et al (2001) The pharmacological profile of δ opioid receptor ligands (+) and (-) TAN-67 on pain modulation. Life Sci. 68 2227 PMID: 11358331

Nagase et al (1994) Syntheses of non-peptidic delta opioid agonists and their structure-activity relationships. Jpn.J.Pharmacol. 64 Suppl. 1, 35P

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2 Citations for SB 205607 dihydrobromide

Citations are publications that use Tocris products. Selected citations for SB 205607 dihydrobromide include:

Robins et al (2018) Critical Role for Gi/o-Protein Activity in the Dorsal Striatum in the Reduction of Voluntary Alcohol Intake in C57Bl/6 Mice. Front Psychiatry 9 112 PMID: 29686629

Nielsen et al (2012) The delta opioid receptor antagonist, SoRI-9409, decreases yohimbine stress-induced reinstatement of ethanol-seeking. Addict Biol 17 224 PMID: 21309957

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Literature in this Area

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