SB 205607 dihydrobromide

Pricing Availability   Qty
Cat.No. 0921 - SB 205607 dihydrobromide | C23H24N2O.2HBr | CAS No. 1217628-73-3
Description: Selective, high affinity non-peptide δ1 agonist
Alternative Names: TAN 67
Chemical Name: (R*,S*)-(±)-2-Methyl-4aa-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12aa-octahydroquinolino[2,3,3-g]isoquinoline dihydrobromide
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

The first described non-peptide δ1 opioid receptor agonist with very high affinity and selectivity for the δ1 subtype (Ki values are 1.12, 2320 and 1790 nM at δ1, μ and κ receptors respectively).

Licensing Information

Sold under license

Technical Data

M. Wt 506.28
Formula C23H24N2O.2HBr
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 1217628-73-3
PubChem ID 56972161
InChI Key GWXFBFMLKRAWEU-YJKXCHRFSA-N
Smiles [H][C@@](C1)2[C@](CC(N=C(C=CC=C4)C4=C3)=C3C2)([C@]5=CC=CC(O)=C5)CCN1C.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 50.63 100
DMSO 50.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 506.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.88 mL 19.75 mL
5 mM 0.4 mL 1.98 mL 3.95 mL
10 mM 0.2 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Kamei et al (1995) Antinociceptive effects of the selective non-peptidic δ-opioid receptor agonist TAN-67 in diabetic mice. Eur.J.Pharmacol. 276 131 PMID: 7781682

Knap et al (1995) Properties of TAN-67, a non-peptidic β-opioid receptor agonist, at cloned human δ- and μ-opioid receptors. Eur.J.Pharmacol. 291 129 PMID: 8566162

Nagase et al (2001) The pharmacological profile of δ opioid receptor ligands (+) and (-) TAN-67 on pain modulation. Life Sci. 68 2227 PMID: 11358331

Nagase et al (1994) Syntheses of non-peptidic delta opioid agonists and their structure-activity relationships. Jpn.J.Pharmacol. 64 Suppl. 1, 35P


If you know of a relevant reference for SB 205607 dihydrobromide, please let us know.

View Related Products by Target

View Related Products by Product Action

View all δ Opioid Receptor Agonists

Keywords: SB 205607 dihydrobromide, SB 205607 dihydrobromide supplier, δ1-opioid, delta1-opioid, selective, high, affinity, non-peptide, agonists, DOP, Receptors, OP1, SB205607, dihydrobromide, TAN67, TAN, 67, Delta, Opioid, 0921, Tocris Bioscience

1 Citation for SB 205607 dihydrobromide

Citations are publications that use Tocris products. Selected citations for SB 205607 dihydrobromide include:

Nielsen et al (2012) The delta opioid receptor antagonist, SoRI-9409, decreases yohimbine stress-induced reinstatement of ethanol-seeking. Addict Biol 17 224 PMID: 21309957


Do you know of a great paper that uses SB 205607 dihydrobromide from Tocris? Please let us know.

Reviews for SB 205607 dihydrobromide

There are currently no reviews for this product. Be the first to review SB 205607 dihydrobromide and earn rewards!

Have you used SB 205607 dihydrobromide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Addiction

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.