DADLE

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Cat.No. 3790 - DADLE | Tyr-D-Ala-Gly-Phe-D-Leu | CAS No. 63631-40-3
Description: Prototypical δ agonist
Alternative Names: [D-Ala2, D-Leu5]-Enkephalin
Datasheet
Citations
Literature

Biological Activity

Prototypical δ-opioid receptor agonist that also displays activity at the μ-opioid receptor. Displays antinociceptive activity in vivo.

Technical Data

M. Wt 569.66
Formula C29H39N5O7
Sequence YAGFL

(Modifications: Ala-2 = D-Ala, Leu-5 = D-Leu)

Storage Store at -20°C
CAS Number 63631-40-3
PubChem ID 6917707
InChI Key ZHUJMSMQIPIPTF-IBURTVSXSA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 569.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.76 mL 8.78 mL 17.55 mL
5 mM 0.35 mL 1.76 mL 3.51 mL
10 mM 0.18 mL 0.88 mL 1.76 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Mulder et al (1991) Pharmacological profile of various κ-agonists at κ-, μ- and δ-opioid receptors mediating presynaptic inhibition of neurotransmitter release in the rat brain. Br.J.Pharmacol. 102 518 PMID: 1673074

Ke et al (2009) Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway. Brain Res. 1292 100 PMID: 19619518

Suh and Tseng (1990) Different types of opioid receptors mediating analgesia induced by morphine, DAMGO, DPDPE, DADLE and beta-endorphin in mice. Naunyn-Schmied.Arch.Pharmacol. 342 67 PMID:


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Citations for DADLE

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Pathways for DADLE

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