Pricing Availability   Qty
Description: Prototypical δ agonist
Alternative Names: [D-Ala2,D-Leu5]-Enkephalin
Purity: ≥95% (HPLC)
Citations (4)
Literature (2)

Biological Activity for DADLE

DADLE is a prototypical δ-opioid receptor agonist that also displays activity at the μ-opioid receptor. Displays antinociceptive activity in vivo.

Technical Data for DADLE

M. Wt 569.66
Formula C29H39N5O7
Sequence YAGFL

(Modifications: Ala-2 = D-Ala, Leu-5 = D-Leu)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 63631-40-3
PubChem ID 6917707
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DADLE

Solubility Soluble to 1 mg/ml in water

Product Datasheets for DADLE

Certificate of Analysis / Product Datasheet
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References for DADLE

References are publications that support the biological activity of the product.

Mulder et al (1991) Pharmacological profile of various κ-agonists at κ-, μ- and δ-opioid receptors mediating presynaptic inhibition of neurotransmitter release in the rat brain. Br.J.Pharmacol. 102 518 PMID: 1673074

Ke et al (2009) Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway. Brain Res. 1292 100 PMID: 19619518

Suh and Tseng (1990) Different types of opioid receptors mediating analgesia induced by morphine, DAMGO, DPDPE, DADLE and beta-endorphin in mice. Naunyn-Schmied.Arch.Pharmacol. 342 67

If you know of a relevant reference for DADLE, please let us know.

View Related Products by Product Action

View all δ Opioid Receptor Agonists

Keywords: DADLE, DADLE supplier, delta-opioid, d-opioid, δ-opioid, receptors, agonists, delta-receptors, prototypical, DOP, OP1, [D-Ala2,, D-Leu5]-Enkephalin, Delta, Opioid, Receptors, 3790, Tocris Bioscience

4 Citations for DADLE

Citations are publications that use Tocris products. Selected citations for DADLE include:

Yuan et al (2020) Opposite Roles of δ- and μ-Opioid Receptors in BACE1 Regulation and Alzheimer's Injury. Front Cell Neurosci 14 88 PMID: 32425755

Shiwarski et al (2017) A PTEN-Regulated Checkpoint Controls Surface Delivery of δ Opioid Receptors. J Neurosci 37 3741 PMID: 28264976

Manojkumar A et al (2017) PI3K class II α regulates δ-opioid receptor export from the trans-Golgi network. Mol Biol Cell 28 2202-2219 PMID: 28566554

David P et al (2019) Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior. Neuropsychopharmacology 44 1728-1741 PMID: 31141817

Do you know of a great paper that uses DADLE from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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