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Biological Activity for DADLE
DADLE is a prototypical δ-opioid receptor agonist that also displays activity at the μ-opioid receptor. Displays antinociceptive activity in vivo.
Technical Data for DADLE
(Modifications: Ala-2 = D-Ala, Leu-5 = D-Leu)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DADLE
|Solubility||Soluble to 1 mg/ml in water|
References for DADLE
References are publications that support the biological activity of the product.
Mulder et al (1991) Pharmacological profile of various κ-agonists at κ-, μ- and δ-opioid receptors mediating presynaptic inhibition of neurotransmitter release in the rat brain. Br.J.Pharmacol. 102 518 PMID: 1673074
Ke et al (2009) Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway. Brain Res. 1292 100 PMID: 19619518
Suh and Tseng (1990) Different types of opioid receptors mediating analgesia induced by morphine, DAMGO, DPDPE, DADLE and beta-endorphin in mice. Naunyn-Schmied.Arch.Pharmacol. 342 67
If you know of a relevant reference for DADLE, please let us know.
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Keywords: DADLE, DADLE supplier, delta-opioid, d-opioid, δ-opioid, receptors, agonists, delta-receptors, prototypical, DOP, OP1, [D-Ala2,, D-Leu5]-Enkephalin, Delta, Opioid, Receptors, 3790, Tocris Bioscience
1 Citation for DADLE
Citations are publications that use Tocris products. Selected citations for DADLE include:
Shiwarski et al (2017) A PTEN-Regulated Checkpoint Controls Surface Delivery of δ Opioid Receptors. J Neurosci 37 3741 PMID: 28264976
Do you know of a great paper that uses DADLE from Tocris? Please let us know.
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Literature in this Area
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