DADLE

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Cat.No. 3790 - DADLE | Tyr-D-Ala-Gly-Phe-D-Leu | CAS No. 63631-40-3
Description: Prototypical δ agonist
Alternative Names: [D-Ala2, D-Leu5]-Enkephalin
Datasheet
Citations (1)
Reviews
Literature (5)

Biological Activity

Prototypical δ-opioid receptor agonist that also displays activity at the μ-opioid receptor. Displays antinociceptive activity in vivo.

Technical Data

M. Wt 569.66
Formula C29H39N5O7
Sequence YAGFL

(Modifications: Ala-2 = D-Ala, Leu-5 = D-Leu)

Storage Store at -20°C
CAS Number 63631-40-3
PubChem ID 6917707
InChI Key ZHUJMSMQIPIPTF-IBURTVSXSA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Mulder et al (1991) Pharmacological profile of various κ-agonists at κ-, μ- and δ-opioid receptors mediating presynaptic inhibition of neurotransmitter release in the rat brain. Br.J.Pharmacol. 102 518 PMID: 1673074

Ke et al (2009) Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway. Brain Res. 1292 100 PMID: 19619518

Suh and Tseng (1990) Different types of opioid receptors mediating analgesia induced by morphine, DAMGO, DPDPE, DADLE and beta-endorphin in mice. Naunyn-Schmied.Arch.Pharmacol. 342 67


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Keywords: DADLE, DADLE supplier, delta-opioid, d-opioid, δ-opioid, receptors, agonists, delta-receptors, prototypical, DOP, OP1, [D-Ala2,, D-Leu5]-Enkephalin, Delta, Opioid, Receptors, 3790, Tocris Bioscience

1 Citation for DADLE

Citations are publications that use Tocris products. Selected citations for DADLE include:

Shiwarski et al (2017) A PTEN-Regulated Checkpoint Controls Surface Delivery of δ Opioid Receptors. J Neurosci 37 3741 PMID: 28264976


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