μ Opioid Receptors

The μ opioid receptor, (also known as OP3, MOP, MOR), is a member of the opioid family of G-protein-coupled receptors that also includes κ, δ and NOP receptors. Three splice variants of the receptor (designated μ1, μ2 and μ3) have been characterized.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
1171 DAMGO
Selective μ agonist
1055 Endomorphin-1
Potent and selective μ agonist
1056 Endomorphin-2
Potent and selective μ agonist
3247 Fentanyl citrate
Potent and selective μ agonist
0840 Loperamide hydrochloride
Peripherally acting μ agonist; Ca2+ channel blocker
3636 Meptazinol hydrochloride
μ1 partial agonist
3958 Oxycodone hydrochloride
μ agonist
2024 PL 017
Selective μ agonist
3848 Sinomenine hydrochloride
μ agonist; antinociceptive and anti-inflammatory

Antagonists

Cat No Product Name / Activity
0898 Clocinnamox mesylate
Irreversible μ antagonist
1560 CTAP
Selective and potent μ antagonist
1578 CTOP
Potent and selective μ antagonist
2601 Cyprodime hydrochloride
Selective μ antagonist
0926 β-Funaltrexamine hydrochloride
Irreversible μ-selective antagonist
0591 Naloxonazine dihydrochloride
Selective μ1 antagonist

The μ opioid receptor, (also known as OP3, MOP, MOR), is a member of the opioid family of G-protein-coupled receptors that also includes κ, δ and NOP receptors. Three variants of the receptor (designated μ1, μ2 and μ3) have been characterized, arising from the alternative splicing of the this gene.

μ Opioid receptors are distributed throughout the neuraxis (neocortex, thalamus, nucleus accumbens, hippocampus, amygdala) and in the peripheral nervous system (myenteric neurons and vas deferens). μ opioid receptors have been implicated in respiration, cardiovascular functions, feeding, learning and memory, intestinal transit, locomotor activity, thermoregulation, hormone secretion and immune functions. The human gene encoding the μ opioid receptor has been localized to chromosome 6 (6q24-q25).

External sources of pharmacological information for μ Opioid Receptors :

Literature for μ Opioid Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

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  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
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Peptides Involved in Appetite Modulation Scientific Review

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Addiction Poster

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Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

μ Opioid Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human OPRM1 NM_000914 P35372
Mouse Oprm1 NM_001039652 P42866
Rat Oprm1 NM_013071 P33535